by Patrice D. Cani
Individuals with obesity and type 2 diabetes have shown an altered gut microbiome composition. A new study has discovered tissue bacterial signatures linked to type 2 diabetes.
by Patrice D. Cani
The gut-dwelling bacterium Akkermansia muciniphila has been positively linked with leanness in mice and humans. A new randomized, double-blind, placebo-controlled pilot study shows that heat-inactivated A. muciniphila may help to limit cardiovascular risk parameters in individuals who are overweight and obese.
by Patrice D. Cani
New developments in genetics and metagenomics over the past 15 years have led scientists to produce an in-depth characterization of the composition and function of the gut microbiome as a novel organ in the close intersection between health and disease.
by Patrice D. Cani
Probiotics have a range of documented effects on human health, with hundreds of studies from the past several decades showing their ability to alter physical or behavioural phenotypes in humans. These human efficacy trials provide the necessary evidence to guide
by Patrice D. Cani
Gut microbiota, with its close links to metabolism and the immune system, could potentially be a factor that lies at the core of good health. This means it can be positioned at the heart of the processes that influence the risk of contracting different diseases.
by Patrice D. Cani
In a recent paper by Perry et al., researchers describe an investigation into the putative mechanisms by which gut microbiota alterations may lead to obesity, insulin resistance, and metabolic syndrome. Authors describe increased production of acetate by altered gut microbiota
by Patrice D. Cani
A recent study (Chassaing, et al.) showed that two dietary emulsifiers -- carboxymethylcellulose and polysorbate-80 -- induced gut microbiota alteration and gut barrier dysfunction in mice, resulting in weight gain, low-grade inflammation, and metabolic disorders. While it is unlikely that
by Patrice D. Cani
In this paper, the first aim we had with Dr. Amandine Everard, was to investigate whether some key molecules involved in the innate immune system, mainly MyD88 [myeloid differentiation primary response gene 88], may contribute to the development of obesity, diabetes
by Patrice D. Cani
Numerous commensal bacteria present in the gut microbiota produce short chain fatty acids (SCFA’s) particularly acetate, butyrate and propionate. These SCFA’s have been associated with several biological effects upon host. Growing evidence suggests that specific microbes such as Faecalibacterium prausnitzii
by Patrice D. Cani
The team of Jeffrey Gordon (Ridaura et al. Science 2013) published that the phenotype of obesity (increased adiposity) of an obese twin in a discordant twin pair is transmissible. In other words, they found that mice receiving an obese twin’s