by Patrice D. Cani
A recent study (Chassaing, et al.) showed that two dietary emulsifiers -- carboxymethylcellulose and polysorbate-80 -- induced gut microbiota alteration and gut barrier dysfunction in mice, resulting in weight gain, low-grade inflammation, and metabolic disorders.
by Patrice D. Cani
In this paper, the first aim we had with Dr. Amandine Everard, was to investigate whether some key molecules involved in the innate immune system, mainly MyD88 [myeloid differentiation primary response gene 88], may contribute to the development of obesity, diabetes and low grade inflammation.
by Patrice D. Cani
Numerous commensal bacteria present in the gut microbiota produce short chain fatty acids (SCFA’s) particularly acetate, butyrate and propionate. These SCFA’s have been associated with several biological effects upon host. Growing evidence suggests that specific microbes such as Faecalibacterium prausnitzii
by Patrice D. Cani
The team of Jeffrey Gordon (Ridaura et al. Science 2013) published that the phenotype of obesity (increased adiposity) of an obese twin in a discordant twin pair is transmissible. In other words, they found that mice receiving an obese twin’s
by Patrice D. Cani
Some individuals seem to be more susceptible to develop obesity or are more resistant to weight loss during dietary restriction. Emerging evidence suggest that few bacterial genera (i.e., Bifidobacterium, Lactobacillus, Faecalibacterium and Akkermansia) are inversely associated with obesity, metabolic inflammation
