Targeted antimicrobials in the oral microbiome

7 Dec 2016

by Melissa Agnello

Most mucosal surfaces of the human body contain an extremely complex ecosystem of microbial organisms. These resident microbes exist in a delicate balance with each other and the human host that is dictated by the specific local environmental factors of each host body site. In health, the many different species that make up the microbiota exist in homeostasis with the host immune system. A dysbiosis of the microbiota shifts the community, which may lead to disease.

Between January 2010 and April 2015, 901 patients with CDI were identified, with a gradual increase over time (2010= 54 patients; 2011= 116 patients; 2012= 200 patients; 2013= 212 patients; 2014= 268 patients; January-April 2015= 71 patients). Thirty-five patients with severe cases underwent FMT: 7 in 2013, 16 in 2014, and 12 between January and April 2015.

Should we exclude obese donors from FMT?

6 Feb 2015

by Philippe Marteau

Neha Alang and Colleen R. Kelly recently reported that a patient who had received fecal microbiota transplantation (FMT) developed obesity (1).