by Karen Madsen
Previous clinical studies have shown a promising role of fecal microbiota transplantation to induce remission in ulcerative colitis and maintain steroid-induced Crohn’s disease remission. A new double-blind, placebo-controlled trial found fecal microbiota transplantation is not effective at inducing clinical or endoscopic remission in adults with Crohn’s disease.
After two decades of scientific exploration, the human microbiome has emerged as a critical determinant of health and disease. Fueled by multi-omics technologies and machine learning, the field has advanced from correlation-based observations to establishing causal relationships. This article presents recent and compelling examples of microbiome-based treatments that are ripe for clinical adoption and discusses challenges and opportunities facing the field based on expert interviews conducted by the GMFH team.
The human gut microbiome is packed with enzymes that can transform food, drugs, or pollutants. New research maps interactions between dietary xenobiotics and the gut microbiome, explaining why diet can work differently for different people.
by Andreu Prados
Fecal microbiota transplantation (FMT) has shown to be efficient in recurrent Clostridioides difficile infection and is being researched in clinical trials for other conditions, but its mechanisms of action remain poorly understood. Two new studies shed light on factors that predict clinical success in FMT.
by GMFH Editing Team
Significant strides have been made in our comprehension of the role of the gut microbiome in health and disease throughout the year 2022. We invite you to take a closer look at the "2022 Year at a Glance" report and learn about the groundbreaking discoveries made.
by GMFH Editing Team
Fecal microbiota transplantation is being studied in the context of metabolic health, beyond its use for recurrent Clostridioides difficile infection. A new proof-of-principle study reveals that supplementing low-fermentable fiber following fecal microbiota transplantation may improve insulin sensitivity in individuals with severe obesity.
by Andreu Prados
The microbiota of infants born by caesarean section resembles that of maternal oral cavity and skin, whereas that of vaginally born infants resembles that of the maternal gut microbiome. A new proof-of-concept study shows that the gut microbiota of C-section-born infants can be restored after delivery via orally administered maternal fecal microbiota transplantation.
by Andreu Prados
An altered balance of the community of microbes that reside in our body, especially within the gut, has been linked to a wide range of intestinal and extraintestinal diseases. What evidence-based strategies are currently available for modulating the gut microbiota?
by Stéphane Schneider
The benefits of fecal microbiota transplantation in treating Clostridioides difficile infection are well documented. Despite this, a new study concerns the transfer of extended-spectrum beta-lactamase-producing Escherichia coli in two immunocompromised adults.
by GMFH Editing Team
GMFH continue to cover the important progress made in our knowledge of the gut microbiota's impact on wellbeing and disease.
