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Gut microbiota produced tryptamine accelerates gastrointestinal tract transit by increasing colonic secretion in mice

9 Aug 2018

by Megan Mouw

A new study sheds some light on the function of bacterially-produced tryptamine in the gut by showing that it increases colonic fluid secretion in mice through activation of serotonin receptor-4, thus accelerating gastrointestinal transit.

The role of gut microbiota in tryptophan metabolism: current evidence and challenges

16 Jul 2018

by GMFH Editing Team

A new review clarifies how the gut microbiota regulates Trp metabolism and identifies the underlying molecular mechanisms of these interactions, based on the pathogenesis of human diseases and potential new treatments.

New research on how tryptophan plus a specific gut microbe might help dampen inflammation

14 Feb 2018

by Kristina Campbell

A new study confirms that help provided by commensal intestinal bacteria present in the GALT (gut-associated lymphoid tissue) means harmless substances from the outside environment can be tolerated.

Interplay between genetics and microbial metabolism contributes to inflammation in the gut

24 Oct 2016

by Heather Galipeau

In a recently published paper in Nature Medicine, a group led by Harry Sokol at INRA studied how host genes affect the composition and function of the gut microbiota, and in turn, the production of metabolites and intestinal inflammation.

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