Much of nutrition science has centred on what we put on our plate, yet when we choose to eat may be just as consequential. Intermittent fasting (IF) has gained attention as a strategy that may support metabolic health while also reshaping microbial rhythms, gut hormone secretion, and intestinal function. The growing interest surrounding this approach raises an essential question for clinical practice: does IF truly translate into measurable benefits?

After two decades of scientific exploration, the human microbiome has emerged as a critical determinant of health and disease. Fueled by multi-omics technologies and machine learning, the field has advanced from correlation-based observations to establishing causal relationships. This article presents recent and compelling examples of microbiome-based treatments that are ripe for clinical adoption and discusses challenges and opportunities facing the field based on expert interviews conducted by the GMFH team.

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