Clostridioides difficile infection is a common cause of diarrhea in both the hospital and community settings, with C. difficile recurrence one of the most challenging outcomes to address. This article focuses on the factors that predict long-term complications of C. difficile infection and what can be done in clinical practice to minimize them (Part 5).

Clostridioides difficile infection is the most frequent cause of antibiotic-associated diarrhea in the hospital setting that has increased in severity. This article looks at the risk factors for developing C. difficile-associated disease, the spectrum of manifestations and the impact of the COVID-19 pandemic on the occurrence of C. difficile infection.