Category : Infections

Antibiotics are known for their capacity to perturb the structure of the gut microbiome, with subsequent complications that go beyond the gastrointestinal tract. How host and gut microbiome-related factors modulate antibiotic susceptibility, however, is poorly understood. As a result, scientists still struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New…

GMFH Editing Team
GMFH Editing Team

Antibiotics are known for their capacity to perturb the structure of the gut microbiome, with subsequent complications that go beyond the gastrointestinal tract. How host and gut microbiome-related factors modulate antibiotic susceptibility, however, is poorly understood. As a result, scientists still struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New…

GMFH Editing Team
GMFH Editing Team

The increase in cardiovascular diseases (CVD) that comes with age has been related to an arterial dysfunction linked to higher inflammatory and oxidative stress responses. Although there is suggestion that a perturbed gut microbiome plays a role in the aging phenotype and the onset of physical frailty, the mechanisms that link changes in gut microbiome composition and an increased risk…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The increase in cardiovascular diseases (CVD) that comes with age has been related to an arterial dysfunction linked to higher inflammatory and oxidative stress responses. Although there is suggestion that a perturbed gut microbiome plays a role in the aging phenotype and the onset of physical frailty, the mechanisms that link changes in gut microbiome composition and an increased risk…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Probiotics have different potential therapeutic uses, although their mechanisms of action and how they might change after administration are not fully studied. In contrast to traditional drugs, probiotics can evolve during treatment, but how this process works inside the gut remains largely elusive. A new study, led by Dr. Gautam Dantas from the Washington University School of Medicine in St.…

GMFH Editing Team
GMFH Editing Team

Probiotics have different potential therapeutic uses, although their mechanisms of action and how they might change after administration are not fully studied. In contrast to traditional drugs, probiotics can evolve during treatment, but how this process works inside the gut remains largely elusive. A new study, led by Dr. Gautam Dantas from the Washington University School of Medicine in St.…

GMFH Editing Team
GMFH Editing Team

Although the human gut microbiome is a source of antibiotic resistance genes (ARGs), until now, the intestinal resistome has not been extensively characterized. Challenges therefore remain, and they include figuring out the gut microbiota's contribution to the total pool of known ARGs and identifying ARGs in metagenomic data, given that they show distant homologies with known genes in databases. Researchers…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Although the human gut microbiome is a source of antibiotic resistance genes (ARGs), until now, the intestinal resistome has not been extensively characterized. Challenges therefore remain, and they include figuring out the gut microbiota's contribution to the total pool of known ARGs and identifying ARGs in metagenomic data, given that they show distant homologies with known genes in databases. Researchers…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

Studies exploring the neonatal microbiome during early life have been performed mainly in the hospital setting, with both mode of delivery and antibiotics having the most profound impact on the microbiome. However, the development of the neonatal microbiome in the absence of routine hospital interventions during delivery has not yet been studied. A new study, led by Prof. Maria Gloria…

GMFH Editing Team
GMFH Editing Team

Studies exploring the neonatal microbiome during early life have been performed mainly in the hospital setting, with both mode of delivery and antibiotics having the most profound impact on the microbiome. However, the development of the neonatal microbiome in the absence of routine hospital interventions during delivery has not yet been studied. A new study, led by Prof. Maria Gloria…

GMFH Editing Team
GMFH Editing Team

The use of antibiotics has long been related to a perturbation of the composition and functions of commensal bacterial communities. Some bacteria die in response to antibiotics while gut microbes that harbor antibiotic resistance genes survive. However, little is known regarding the impact of antibiotics on the eradication and recovery of gut microorganisms. A new study, led by Prof. Oluf…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The use of antibiotics has long been related to a perturbation of the composition and functions of commensal bacterial communities. Some bacteria die in response to antibiotics while gut microbes that harbor antibiotic resistance genes survive. However, little is known regarding the impact of antibiotics on the eradication and recovery of gut microorganisms. A new study, led by Prof. Oluf…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Western diets high in fats and sugars, modern lifestyles with stress and sedentarism and the indiscriminate use of antibiotics together with other frequently prescribed drugs -such as non-steroidal anti-inflammatory drugs and proton pump inhibitors- are major drivers of changes in microbiota composition and gut barrier disruption. (Dr. Maria Rescigno) The GMFH publishing team is pleased to share a new summary…

GMFH Editing Team
GMFH Editing Team

Western diets high in fats and sugars, modern lifestyles with stress and sedentarism and the indiscriminate use of antibiotics together with other frequently prescribed drugs -such as non-steroidal anti-inflammatory drugs and proton pump inhibitors- are major drivers of changes in microbiota composition and gut barrier disruption. (Dr. Maria Rescigno) The GMFH publishing team is pleased to share a new summary…

GMFH Editing Team
GMFH Editing Team

The gut microbiota has wide-ranging effects on host physiology and is an important determinant of health and disease. As we have learned over the past two decades, these effects are not limited to the gastrointestinal tract, but can influence host functions throughout the body.  A great deal of research has focused on understanding the mechanisms by which microbes influence host…

Heather Galipeau
Heather Galipeau is a Research Associate at McMaster University (Canada) where she is researching dietary and microbial interactions in celiac disease and inflammatory bowel disease. She obtained her PhD in 2015 from McMaster University in Elena Verdu’s lab, during which she found that the small intestinal microbial background influences the degree of immuno-pathology triggered by dietary antigens, such as gluten.

The gut microbiota has wide-ranging effects on host physiology and is an important determinant of health and disease. As we have learned over the past two decades, these effects are not limited to the gastrointestinal tract, but can influence host functions throughout the body.  A great deal of research has focused on understanding the mechanisms by which microbes influence host…

Heather Galipeau
Heather Galipeau is a Research Associate at McMaster University (Canada) where she is researching dietary and microbial interactions in celiac disease and inflammatory bowel disease. She obtained her PhD in 2015 from McMaster University in Elena Verdu’s lab, during which she found that the small intestinal microbial background influences the degree of immuno-pathology triggered by dietary antigens, such as gluten.