Circadian rhythms are also apparent within our gastrointestinal tract. Two new mice studies show that circadian rhythm and clock genes may also affect intestinal immune cells by boosting the secretion of cytokines that help maintain proper balance of the intestinal barrier.
The availability of glucose and fiber in diet shapes gut microbiome susceptibility to antibiotics in mice
30 Sep 2019by GMFH Editing Team
Scientists struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New research in mice reveals that gut microbial metabolism alongside diet play a key role in modifying the extent of gut microbiome disruption in response to antibiotics.
Gut microbiome changes emerge as a potential modulator of age-associated cardiovascular disease risk
15 Apr 2019by Andreu Prados
The mechanisms that link changes in gut microbiome composition and an increased risk of cardiovascular disease remain elusive. Changes in the gut microbiome related to aging may mediate arterial dysfunction, coupled with a normalization of inflammation, suggests a new mice study.
The gut microbiome, diet and antibiotic treatment all shape E. coli Nissle evolution in the mouse gut
11 Apr 2019by GMFH Editing Team
Contrary to common drugs, probiotics can evolve during treatment within the host. Scientists have tracked the behavior of E. coli Nissle 1917 in the mouse’s gut and shown that unbalanced gut microbiomes and different diets may affect how this bacterium evolves across the gastrointestinal tract.
The most significant achievements in gut microbiome science in 2018
27 Dec 2018by GMFH Editing Team
GMFH continue to cover the important progress made in our knowledge of the gut microbiota's impact on wellbeing and disease.
Scientists characterize antibiotic resistance genes in metagenomic data based on the 3D structure of the proteins they encode
20 Dec 2018by Andreu Prados
The University of Birmingham and King’s College have developed a new bioinformatics gene function prediction method
Regulatory T cells improve gut barrier integrity through preserving colonic short-chain fatty acid levels in cirrhotic mice
13 Dec 2018by Oriol Juanola & Rubén Francés
Mice without the capacity to produce mature B and T lymphocytes showed an increased gut permeability.
Hospital delivery may have short-term implications for both maternal vaginal and neonate fecal microbiota
10 Dec 2018by GMFH Editing Team
The researchers analyzed the structure of stool microbiota from vaginally.
Gut microbe populations in healthy adults may achieve almost full recovery after short-term antibiotics intervention
6 Dec 2018by Andreu Prados
A new study, led by Prof. Oluf Pedersen from the Faculty of Health and Medical Sciences at the University of Copenhagen (Denmark), has found that most gut bacterial species recover.
New GMFH “best of” document highlights the latest research on the gut barrier
19 Nov 2018by GMFH Editing Team
Western diets high in fats and sugars, modern lifestyles with stress and sedentarism and the indiscriminate use of antibiotics together with other frequently prescribed drugs -such as non-steroidal anti-inflammatory drugs and proton pump inhibitors- are major drivers of changes in microbiota composition and gut barrier disruption. (Dr. Maria Rescigno)
