Now a recent study, led by Dr. Nicola Santoro from the Department of Paediatrics at Yale University in New Haven, Connecticut (USA), has found that the gut microbiota of obese youth may drive a higher accumulation of energy than that of lean adolescents through an elevated production of short-chain fatty acids (SCFAs) and a higher capability to oxidize carbohydrates.

In a recent paper by Perry et al., researchers describe an investigation into the putative mechanisms by which gut microbiota alterations may lead to obesity, insulin resistance, and metabolic syndrome. Authors describe increased production of acetate by altered gut microbiota in rats. They link this to activation of the parasympathetic nervous system, increased glucose-stimulated insulin secretion, higher ghrelin secretion, hyperphagia, and obesity. Thus, they point to increased acetate production as a driver of metabolic syndrome.

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