After two decades of scientific exploration, the human microbiome has emerged as a critical determinant of health and disease. Fueled by multi-omics technologies and machine learning, the field has advanced from correlation-based observations to establishing causal relationships. This article presents recent and compelling examples of microbiome-based treatments that are ripe for clinical adoption and discusses challenges and opportunities facing the field based on expert interviews conducted by the GMFH team.
Two hospitals in Barcelona, the Clínic and Bellvitge, have launched Spain's first Fecal Microbiota Bank. Their goal is to obtain donations of stool from healthy individuals to perform microbiota transplants on patients suffering from potentially fatal infections of bacteria known as C. difficile infections. We step into the fecal microbiota transfer units of both hospitals to learn how they operate and meet some of the donors.
The ultimate goal would be to create an "artificial stool", a consortium of commensal bacteria fermented and harvested in vitro,
