After two decades of scientific exploration, the human microbiome has emerged as a critical determinant of health and disease. Fueled by multi-omics technologies and machine learning, the field has advanced from correlation-based observations to establishing causal relationships. This article presents recent and compelling examples of microbiome-based treatments that are ripe for clinical adoption and discusses challenges and opportunities facing the field based on expert interviews conducted by the GMFH team.
Harvard group engineers bacteria with a ‘memory’ for gut inflammation in mice
10 Jul 2017by Kristina Campbell
New work, led by Pamela Silver of The Wyss Institute of Biologically Inspired Engineering at Harvard (USA), appears to have overcome this problem. The research, which has been called "incredibly exciting" by other scientists, involved the design of a bacterial trigger circuit that detects and responds to tetrathionate—a transient product of reactive oxygen species.
