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2025 has been a productive year in gut microbiome research, spanning metabolic health, neurogastroenterology, immune modulation, and precision nutrition. In this ‘Year in Review’ article, the GMFH editing team describes their pick of the top GMFH-covered advances in 2025, outlining their impact in the clinical setting and implications for current and future research.

Emerging studies suggest the gut microbiome may predict how well you age. The world’s oldest person offers scientists new clues into the secrets of healthy aging and protection against the diseases that often plague the final years of life.

Previous clinical studies have shown a promising role of fecal microbiota transplantation to induce remission in ulcerative colitis and maintain steroid-induced Crohn’s disease remission. A new double-blind, placebo-controlled trial found fecal microbiota transplantation is not effective at inducing clinical or endoscopic remission in adults with Crohn’s disease.

Vaccines have been protecting us from infectious diseases for over 200 years. Interestingly, recent research suggests unexpected players may be at work behind the scenes: the trillions of microbes that comprise our gut microbiota. Researchers continue to explore how gut microbiota influence immunity, why vaccine responses vary, and whether diet and prebiotics can tip the balance in our favour.

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