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Alterations in the composition and function of the gut microbiota are recognized as key contributors to the pathophysiology of IBS. In this interview with Prof. Carmelo Scarpignato, we discuss the knowns and unknowns of gut microbiota in IBS, the four levels of gut microbiota manipulation, and examples of microbiota-targeted approaches available for the clinician.

Beyond genetics and lifestyle, the gut microbiome is now emerging as an important factor in cancer progression and treatment response. This raises an important question: could understanding and targeting this ecosystem transform the way we treat cancer?

The fifth edition of IBS Days delved into the latest developments in IBS research and clinical management. This article aims to explore causes that can be misdiagnosed as IBS and non-pharmacological strategies targeting gut barrier and gut microbiome dysfunction.

Crohn’s disease is an inflammatory bowel disease linked to an imbalance in the gut microbiome. Now, researchers at McMaster University have found in mice a way to target and 'turn off' only the bad gut bacteria using specially trained, precision viruses. This breakthrough paves the way for treatments tailored to each patient.

Digestive symptoms with an impact on quality of life (QoL) affect one in four adults in the general population worldwide who do not qualify for a diagnosis of a Disorder of Gut-Brain Interaction (DGBI). Recent research suggests this ‘sub-diagnostic’ group demands additional investigation and might benefit from targeted interventions, including dietary interventions.

Dietary fiber is often seen as essential for gut health. However, is it always beneficial? New research challenges this idea, highlighting that not all fibers act the same and that context, type, and dose matter.

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