During the 5th Gut Microbiota for Health World Summit 2016, held in Miami, we had the opportunity to talk to Francisco Guarner, group leader at the Unit of Intestinal Physiopathology at Vall d’Hebron Hospital (Barcelona) and member of the Gut Microbiota for Health Scientific Committee, and Gail Hecht, professor at the Department of Medicine at Loyola University Chicago and 2016 Gut Microbiota for Health World Summit Scientific Committee Chair. They explain, in this double interview, how gut microbiota discoveries can impact our health.