What shapes HIV-1 Envelope gp41 antibody response?

This article, published in Cell Host & Microbe, looked at human immunodeficiency virus, type 1 (HIV-1) Envelope gp41 antibodies. (Gp41 is a protein on the surface of HIV that helps the virus invade the host’s cells; it is of interest to those aiming to develop HIV vaccines.)

Researchers wanted to know what shaped gp41 antibody response to HIV-1. Their findings supported the hypothesis that the dominant HIV-1 gp41 antibody response after HIV-1 transmission is mediated by previously-activated memory B cells in the intestine. These cells are present even before HIV-1 infection and are cross-reactive with intestinal bacteria.

The preinfection B cell repertoire to environmental antigens shapes the postinfection B cell response to HIV-1. Commensal bacteria, as part of the preinfection ‘environment’, may play critical roles in shaping the response to HIV-1.

HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

 

Trama, et al. (2014) HIV-1 Envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria. Cell Host & Microbe. http://dx.doi.org/10.1016/j.chom.2014.07.003

Kristina Campbell
Kristina Campbell
Science writer Kristina Campbell (M.Sc.), from British Columbia (Canada), specializes in communicating about the gut microbiota, digestive health, and nutrition. Author of the best selling Well-Fed Microbiome Cookbook, her freelance work has appeared in publications around the world. Kristina joined the Gut Microbiota for Health publishing team in 2014.  Find her on: GoogleTwitter