Differences in the gut microbiota in patients with IBD compared to healthy controls suggest that probiotics may be of help. This article takes an in-depth look into the rationale of using probiotics for IBD and summarizes the evidence from recent clinical guidelines for the use of probiotics in Crohn’s disease, ulcerative colitis and pouchitis.
Study identifies a role for bacterial proteases in Crohn’s disease
26 Jun 2023by Amber Hann, Heather Galipeau
Inflammatory bowel disease is a chronic remitting and relapsing condition that causes severe inflammation of the intestines and disabling bowel symptoms. It affects millions of lives globally, and although alterations in the gut microbiome have been associated with IBD, precise mechanisms remain incompletely understood. New research from McMaster University now implicates bacterial proteases in Crohn’s disease.
Which dietary components should be promoted, and which ones should be limited in inflammatory bowel disease?
19 May 2023by GMFH Editing Team
What to eat or not to eat as a means of reducing IBD symptoms is one of the main queries a patient might have following diagnosis. Although there is no simple answer and dietary changes are not a substitute for medical therapy, to help consider this question, we have prepared a new infographic on the dietary components to promote and limit in patients with IBD.
Gut microbiota and host inflammation states: personalized treatments for ulcerative colitis remission
15 Nov 2021by GMFH Editing Team
Ulcerative colitis is a chronic debilitating inflammatory bowel disease with no curative treatment currently available. INRAE scientists have developed a novel predictive model of disease progression in pediatric patients that integrates both gut microbiota and host inflammation data.
Fecal bacterial protease activity may indicate progression to ulcerative colitis
14 Dec 2020by Heather Galipeau
Many studies have reported changes in gut microbiome composition in patients with inflammatory bowel disease, including ulcerative colitis, when compared with healthy individuals. While that clearly raises the question about the key role played by gut microbes in IBD pathogenesis, we have yet to pinpoint the causative microbes and their mechanisms.
New research sheds light on the effects of inflammatory bowel disease risk alleles on gut bacterial taxa
8 Apr 2019by GMFH Editing Team
Scientists struggle with elucidating how host and gut microbiome interact for shaping the genetic susceptibility of IBD. In 633 IBD patients, Harry Sokol and colleagues have found associations between genetic variants associated with a higher risk of IBD and the depletion of certain gut bacterial taxa.
Baseline gut microbiome is associated with disease severity, progression and treatment efficacy in pediatric ulcerative colitis patients
26 Nov 2018by Andreu Prados
The researchers investigated the role of the gut microbiome in disease severity, progression and treatment response in 405 pediatric.
A new study has confirmed that certain oral bacteria can travel to the intestine and alter the balance of the gut microbiota, leading to the development of chronic intestinal diseases.
A new study has identified a gut microbial signature for Crohn’s disease that could avoid invasive diagnostic testing
13 Mar 2017by Andreu Prados
A recent study, led by Dr. Chaysavanh Manichanh from the Group of Physiology and Digestive Physiopathology of the Vall d’Hebron Research Institute in Barcelona (Spain), has identified for the first time a group of 8 bacterial taxa that could discriminate CD and non-CD independently of geographical region.
