Tag Archives: Intestinal epithelial barrier

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

The intestinal epithelium is considered a novel target for addressing several acute and chronic gastrointestinal conditions. It also could have a potential role in targeting systemic diseases. It is an active component of the mucosal immune system. When considering the complex ecosystem combining the gastrointestinal epithelium, immune cells and resident microbiota, several probiotics like Lactobacillus fermentum exhibit immunoregulatory effects in…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

The intestinal epithelium is considered a novel target for addressing several acute and chronic gastrointestinal conditions. It also could have a potential role in targeting systemic diseases. It is an active component of the mucosal immune system. When considering the complex ecosystem combining the gastrointestinal epithelium, immune cells and resident microbiota, several probiotics like Lactobacillus fermentum exhibit immunoregulatory effects in…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.