Challenges and next steps in using human fecal microbiota transfer to germ-free mice models as a means of translating microbiome science to therapeutic medicine
2 Jul 2020by Rene van den Wijngaard
Human microbiota-associated mice studies are considered a cornerstone model in microbiome research and may contribute to microbiome-based therapies moving quickly towards clinical use. A new perspective from Jens Walter and colleagues explores the model’s limitations and makes suggestions for improving experimental rigor when testing for causality in microbiome research.