While fecal microbiota transplants are recommended for multiple recurrent Clostridioides difficile infection, their use in clinical practice is hindered by a lack of regulation and understanding of the underlying ecological dynamics. This article covers major challenges for the treatment in transitioning from bench to bedside, from the scientific, clinical and regulatory perspectives (Part 6).

November, Clostridioides difficile infection awareness month

11 Nov 2022

by Konstantina Zafeiropoulou

Just one month before friends and families gather around the Christmas table, November is here to bring awareness around Clostridioides difficile infection, and the importance of microbiota-derived treatments. With this post, all of us in GMFH aim to highlight the importance of protecting ourselves and families and stopping the spread of this potentially deadly infection.

Fecal microbiota transplantation is being studied in the context of metabolic health, beyond its use for recurrent Clostridioides difficile infection. A new proof-of-principle study reveals that supplementing low-fermentable fiber following fecal microbiota transplantation may improve insulin sensitivity in individuals with severe obesity.

The microbiota of infants born by caesarean section resembles that of maternal oral cavity and skin, whereas that of vaginally born infants resembles that of the maternal gut microbiome. A new proof-of-concept study shows that the gut microbiota of C-section-born infants can be restored after delivery via orally administered maternal fecal microbiota transplantation.

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