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Outnumbering our own cells more than 10 to one, the microbes thriving peacefully in the human body help keep us healthy. Recently, research findings have showed that microbial guests may also aid in the treatment of disease. Some of those studies were summarised by Elisabeth Pennisi in the “News and analysis” section of the Science Magazine, in an article titled “Cancer therapies use a little help from microbial friends”, in November 2013.   Pennisi highlighted two studies carried out in mice that illustrated the complex interplay of microbial activity and function with the immune system and therapies. In particular, the authors of both studies found that gut bacteria bolstered the…

In this video Dr. Jeffrey Bland discusses recent research into the gut microbiome. Some of the research cited includes work done by the Cleveland Clinic showing certain gut microbiota may convert animal products consumed in…

Faecal microbiota transplantation (FMT) has emerged as an effective treatment for Clostridium difficile infections that were stubborn to antibiotic therapy. However, other clinical indications of FMT are receiving an increasing attention due to the relevant roles of the microbiota in the function of the gastrointestinal tract and other aspects of human physiology. In consequence, studies of FMT for recurrent Clostridium difficile infection or other indications could require submission of an investigational new drug (IND) application. An IND application is required in the United States by the US Food and Drug Administration (FDA). The FDA regulates clinical studies to evaluate their safety and efficacy, and the IND is necessary whenever clinical…

This basic research sought to better understand how soluble dietary fibers exert their beneficial effect on body weight and glucose control. The researchers show that two short-chain fatty acids, which are produced by fermentation of soluble fiber by gut bacteria, activate intestinal gluconeogenesis (IGN) gene expression through different, but complementary, mechanisms. One of the mechanisms activates IGN gene expression through a gut-brain neural circuit. Researchers observed that the regulation of IGN in mice is crucial for realizing the metabolic benefits associated with ingestion of soluble fiber. Here is the key point of the study from Gilles Mithieux lab : Propionate directly initiates portal-brain neural communication. Butyrate and propionate induce intestinal gluconeogenesis…

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Latest articles

Outnumbering our own cells more than 10 to one, the microbes thriving peacefully in the human body help keep us healthy. Recently, research findings have showed that microbial guests may also aid in the treatment of disease. Some of those studies were summarised by Elisabeth Pennisi in the “News and analysis” section of the Science Magazine, in an article titled “Cancer therapies use a little help from microbial friends”, in November 2013.   Pennisi highlighted two studies carried out in mice that illustrated the complex interplay of microbial activity and function with the immune system and therapies. In particular, the authors of both studies found that gut bacteria bolstered the…

In this video Dr. Jeffrey Bland discusses recent research into the gut microbiome. Some of the research cited includes work done by the Cleveland Clinic showing certain gut microbiota may convert animal products consumed in…

Faecal microbiota transplantation (FMT) has emerged as an effective treatment for Clostridium difficile infections that were stubborn to antibiotic therapy. However, other clinical indications of FMT are receiving an increasing attention due to the relevant roles of the microbiota in the function of the gastrointestinal tract and other aspects of human physiology. In consequence, studies of FMT for recurrent Clostridium difficile infection or other indications could require submission of an investigational new drug (IND) application. An IND application is required in the United States by the US Food and Drug Administration (FDA). The FDA regulates clinical studies to evaluate their safety and efficacy, and the IND is necessary whenever clinical…

This basic research sought to better understand how soluble dietary fibers exert their beneficial effect on body weight and glucose control. The researchers show that two short-chain fatty acids, which are produced by fermentation of soluble fiber by gut bacteria, activate intestinal gluconeogenesis (IGN) gene expression through different, but complementary, mechanisms. One of the mechanisms activates IGN gene expression through a gut-brain neural circuit. Researchers observed that the regulation of IGN in mice is crucial for realizing the metabolic benefits associated with ingestion of soluble fiber. Here is the key point of the study from Gilles Mithieux lab : Propionate directly initiates portal-brain neural communication. Butyrate and propionate induce intestinal gluconeogenesis…

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