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Gnotobiotic animals have long been used to highlight major functions of the intestinal microbiota such as its contribution to trophic development of gut tissues, immune maturation, direct protection from colonization/proliferation of pathogens (the barrier effect) and more recently its implication in metabolism and fat storage. Yet gnotobiology had never been used in a systematic way as a screening tool. This is what JJ Faith and colleagues are presenting in their paper published Jan 22, 2014 in J. J. Faith, P. P. Ahern, V. K. Ridaura, J. Cheng, J. I. Gordon, Identifying gut microbe–host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci. Transl. Med. 6, 220ra11 (2014). The approach used…

The beneficial effects of dietary fibers on gastrointestinal inflammatory disorders has been widely studied. However, the consequences of dietary fiber intake on inflammation outside of the intestine, for instance, in the lung has been poorly documented. Here, Trompette and colleagues showed that dietary fiber content changed the composition of the gut and lung microbiota in mice, in particular by altering the ratio of Firmicutes to Bacteroidetes. They observed that low-fiber diet (<0.3%) led to microbiota dominated by Firmicutes. By contrast, the proportion of Bacteroidaceae was found increased in mice fed a diet rich in fiber (4% supplemented with 30% cellulose or pectin). Interestingly, it was previously reported that Bacteroidetes phylum…

Catherine Juste studied agronomic engineering, and then became Doctor of Science, specializing in nutrition and physiology. She became passionate about environmental microbiology and is currently developing environmental proteomics of the gut microbes at INRA. She…

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Latest articles

Gnotobiotic animals have long been used to highlight major functions of the intestinal microbiota such as its contribution to trophic development of gut tissues, immune maturation, direct protection from colonization/proliferation of pathogens (the barrier effect) and more recently its implication in metabolism and fat storage. Yet gnotobiology had never been used in a systematic way as a screening tool. This is what JJ Faith and colleagues are presenting in their paper published Jan 22, 2014 in J. J. Faith, P. P. Ahern, V. K. Ridaura, J. Cheng, J. I. Gordon, Identifying gut microbe–host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci. Transl. Med. 6, 220ra11 (2014). The approach used…

The beneficial effects of dietary fibers on gastrointestinal inflammatory disorders has been widely studied. However, the consequences of dietary fiber intake on inflammation outside of the intestine, for instance, in the lung has been poorly documented. Here, Trompette and colleagues showed that dietary fiber content changed the composition of the gut and lung microbiota in mice, in particular by altering the ratio of Firmicutes to Bacteroidetes. They observed that low-fiber diet (<0.3%) led to microbiota dominated by Firmicutes. By contrast, the proportion of Bacteroidaceae was found increased in mice fed a diet rich in fiber (4% supplemented with 30% cellulose or pectin). Interestingly, it was previously reported that Bacteroidetes phylum…

Catherine Juste studied agronomic engineering, and then became Doctor of Science, specializing in nutrition and physiology. She became passionate about environmental microbiology and is currently developing environmental proteomics of the gut microbes at INRA. She…

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