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The intestinal microbiota is known to modulate bioavailability and efficacy of endogenous compounds, nutrients or drugs, with large interindividual variations. The least conserved fraction of our microbiota may hence explain a stratification of the human population in converters and non converters for numerous compounds. As an example, the reduction of cholesterol to coprostanol is only active in a fraction of the human population and it is directly associated with the population levels of active Bacteroides dorei (Gerard et al. 2007). The team of Peter Turnbaugh (Haiser et al. Science 2013) just published that Egghertella lenta, an actinobacterium of the human intestinal microbiota, can metabolize the drug Digoxin, used in cardiac…

A conference about relation between gut microbiota and colorectal cancer (CRC) was organized by the Canceropole in Paris this June 28th. Experts presented their studies linking different topics : the host microbiota crosstalk, associations between bacteria and cancer and how microbiota could impact antibiotics and anticancer therapies.   Gerard Eberl from Pasteur Institute started the conference insisting about the importance of microbiota and its potential symbiosis regarding mucosal immunity. Gut microbiota is different among different niches and in case of disease, microbes could take some advantage to growth in specific niche. Host and its microbiota could be seen as a super-organism, a holobiont. There is equilibrium between the microbiota and…

Using mice models, scientists from UCL and WUR found that Akkermansia muciniphila could have a role in reversing high-fat diet-induced metabolic disorders, in this study obesity and type-2 diabetes. The two first authors, Amandine Everard…

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Latest articles

The intestinal microbiota is known to modulate bioavailability and efficacy of endogenous compounds, nutrients or drugs, with large interindividual variations. The least conserved fraction of our microbiota may hence explain a stratification of the human population in converters and non converters for numerous compounds. As an example, the reduction of cholesterol to coprostanol is only active in a fraction of the human population and it is directly associated with the population levels of active Bacteroides dorei (Gerard et al. 2007). The team of Peter Turnbaugh (Haiser et al. Science 2013) just published that Egghertella lenta, an actinobacterium of the human intestinal microbiota, can metabolize the drug Digoxin, used in cardiac…

A conference about relation between gut microbiota and colorectal cancer (CRC) was organized by the Canceropole in Paris this June 28th. Experts presented their studies linking different topics : the host microbiota crosstalk, associations between bacteria and cancer and how microbiota could impact antibiotics and anticancer therapies.   Gerard Eberl from Pasteur Institute started the conference insisting about the importance of microbiota and its potential symbiosis regarding mucosal immunity. Gut microbiota is different among different niches and in case of disease, microbes could take some advantage to growth in specific niche. Host and its microbiota could be seen as a super-organism, a holobiont. There is equilibrium between the microbiota and…

Using mice models, scientists from UCL and WUR found that Akkermansia muciniphila could have a role in reversing high-fat diet-induced metabolic disorders, in this study obesity and type-2 diabetes. The two first authors, Amandine Everard…

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