Host immune response affects gut colonization resistance through the microbiota

In this recent Immunity paper, researchers wanted to know whether host immune response can mediate pathogen colonization resistance through regulation of the gut microbiota. In mice deficient in ID2 (a transcriptional regulator necessary in the development of innate lymphoid cell progenitors), researchers observed that gut colonization resistance against Citrobacter rodentium was significantly impaired. They found that ID2 is essential for mediating colonization resistance, with interleukin-22 from ILC3s controlling resistance by regulating the gut microbiota.

Guo X, et al. (2015) Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota. Immunity DOI: http://dx.doi.org/10.1016/j.immuni.2015.03.012

Paul Enck
Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.