Gut dysbiosis and gastrointestinal complaints do not ameliorate after weight gain in anorexia nervosa patients

post Gut dysbiosis and gastrointestinal complaints do not ameliorates

Beyond affecting host metabolism, the gut microbiota may be able to shape brain function and behaviour through the microbiota-gut-brain axis. A recent study, led by Dr. John Penders, from the Department of Medical Microbiology at Maastricht University Medical Centre (The Netherlands), has found that gut dysbiosis and gastrointestinal complaints in anorexia nervosa patients do not recover after weight gain and/or normalisation of eating behaviour.


The researchers aimed to study the role of gut microbiota in anorexia nervosa (AN) by investigating faecal microbiota and short-chain fatty acids (SCFA) in these patients, along with dietary intake and gastrointestinal complaints, before (n = 55) and after (n = 44) weight gain, in comparison with normal-weight participants (NW, n = 55).


The researchers found profound microbial perturbations in AN patients as compared to NW participants, with higher levels of mucin and protein degrading taxa and members of Clostridium clusters I, XI and XVIII, and reduced levels of carbohydrate utilising taxa, including the butyrate-producing Roseburia spp. Interestingly, the restrictive and binge/purging AN-subtypes featured distinct alterations in microbial community compositions. Short-chain fatty acids (SCFAs, including acetate, propionate, and butyrate)end products of carbohydrate fermentation in the colon were normal in AN patients.


Some upper and lower gastrointestinal symptoms improved in the course of weight gain whereas others did not. The concentrations of branched chain fatty acids (BCFA, consisting of isobutyrate and isovalerate)products of protein fermentationwere increased before and after weight gain when compared to NW participants.


To sum up, the gut microbiota and BCFAs of AN patients are altered in comparison to NW participants and neither the dysbiosis, BCFA profiles, nor gastrointestinal complaints recovered after weight gain.




Mack I, Cuntz U, Grämer C, et al. Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acids profiles, and gastrointestinal complaints. Sci Rep. 2016; 6:26752. doi:10.1038/srep26752.

Paul Enck
Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.