Category : SCFA

This article has been coauthored by Marina Pérez-Gordo, Cristobalina Mayorga and Mariona Pascal. Allergic diseases include heterogenous inflammatory pathologies such as respiratory, cutaneous and food allergies. They are characterized by an immunological response with T lymphocytes as the main effector T cells, which promote the induction of other effector cells involved in allergic inflammation, such as mast cells, basophils, and…

Marina Pérez-Gordo
Basic Medical Science Department, Faculty of Medicine, CEU San Pablo University, ARADyAL, Madrid, Spain. Institute of Applied and Molecular Medicine (IMMA), Faculty of Medicine, CEU San Pablo University, Madrid, Spain.

This article has been coauthored by Marina Pérez-Gordo, Cristobalina Mayorga and Mariona Pascal. Allergic diseases include heterogenous inflammatory pathologies such as respiratory, cutaneous and food allergies. They are characterized by an immunological response with T lymphocytes as the main effector T cells, which promote the induction of other effector cells involved in allergic inflammation, such as mast cells, basophils, and…

Marina Pérez-Gordo
Basic Medical Science Department, Faculty of Medicine, CEU San Pablo University, ARADyAL, Madrid, Spain. Institute of Applied and Molecular Medicine (IMMA), Faculty of Medicine, CEU San Pablo University, Madrid, Spain.

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

Considering that diet is—together with medication—one of the major influencing factors with regards to gut microbiota composition, research is now focusing on how dietary nutrients may affect gut microbial communities. Specifically, an association was previously found between essential omega-3 fatty acid DHA (docosahexaenoic acid) and gut microbiome diversity in healthy elderly people. However, evidence from randomized trials assessing the effect…

Stéphane Schneider
Professor Stéphane Schneider heads the Nutritional Support Unit in the Gastroenterology and Nutrition Department Archet University Hospital in Nice (France). He is also head of the Nice University Hospital’s food-nutrition liaison committee. Dr. Schneider is vice-president of the French-Speaking Society for Clinical Nutrition and Metabolism (SFNEP), and chairs the Educational and Clinical Practice Committee of the European Society for Clinical Nutrition and Metabolism (ESPEN). Three years after receiving his M.D. in Gastroenterology from the University of Nice Sophia-Antipolis, he became an assistant Professor and later a full Professor of Nutrition. He is also certified by the European Board of Gastroenterology and Hepatology. He obtained a Master of Science from the University of Paris VII, and a Ph.D. in nutrition from the University Paul Cezanne, as well as a CME Diploma from Harvard Medical School. His main research interests are intestinal failure and the effects of aging and chronic diseases on nutritional status. He has published 188 articles in peer-reviewed scientific journals, with an h index of 37. His goal is to help understand better the role of the intestinal ecosystem, as well as the effects of different forms of bacteriotherapy, in digestive and non-digestive disorders featuring dysbiosis.

Considering that diet is—together with medication—one of the major influencing factors with regards to gut microbiota composition, research is now focusing on how dietary nutrients may affect gut microbial communities. Specifically, an association was previously found between essential omega-3 fatty acid DHA (docosahexaenoic acid) and gut microbiome diversity in healthy elderly people. However, evidence from randomized trials assessing the effect…

Stéphane Schneider
Professor Stéphane Schneider heads the Nutritional Support Unit in the Gastroenterology and Nutrition Department Archet University Hospital in Nice (France). He is also head of the Nice University Hospital’s food-nutrition liaison committee. Dr. Schneider is vice-president of the French-Speaking Society for Clinical Nutrition and Metabolism (SFNEP), and chairs the Educational and Clinical Practice Committee of the European Society for Clinical Nutrition and Metabolism (ESPEN). Three years after receiving his M.D. in Gastroenterology from the University of Nice Sophia-Antipolis, he became an assistant Professor and later a full Professor of Nutrition. He is also certified by the European Board of Gastroenterology and Hepatology. He obtained a Master of Science from the University of Paris VII, and a Ph.D. in nutrition from the University Paul Cezanne, as well as a CME Diploma from Harvard Medical School. His main research interests are intestinal failure and the effects of aging and chronic diseases on nutritional status. He has published 188 articles in peer-reviewed scientific journals, with an h index of 37. His goal is to help understand better the role of the intestinal ecosystem, as well as the effects of different forms of bacteriotherapy, in digestive and non-digestive disorders featuring dysbiosis.

The ability to distinguish between “self” and “non-self” is the hallmark of a healthy immune system. Immune cells must be able to recognize pathogenic “non-self” antigens (i.e. microbial pathogens) and mount an appropriate immune response while remaining quiescent towards “self” agents (i.e. commensal microbes) that are harmless to our health. Nowhere else in the human body is this process more…

Megan Mouw
Megan Mouw holds a Bachelor of Science in microbiology from McGill University (Canada). Driven by her experiences at UCSF medical center in San Francisco, Megan is passionate about the role that the gut microbiota plays in maintaining health and wellness. She is currently perusing graduate studies in Microbiology and Environmental Toxicology at the University of California Santa Cruz and hopes to share her love of science through writing.

The ability to distinguish between “self” and “non-self” is the hallmark of a healthy immune system. Immune cells must be able to recognize pathogenic “non-self” antigens (i.e. microbial pathogens) and mount an appropriate immune response while remaining quiescent towards “self” agents (i.e. commensal microbes) that are harmless to our health. Nowhere else in the human body is this process more…

Megan Mouw
Megan Mouw holds a Bachelor of Science in microbiology from McGill University (Canada). Driven by her experiences at UCSF medical center in San Francisco, Megan is passionate about the role that the gut microbiota plays in maintaining health and wellness. She is currently perusing graduate studies in Microbiology and Environmental Toxicology at the University of California Santa Cruz and hopes to share her love of science through writing.

Short-chain fatty acids (SCFAs) (such as acetate, propionate, butyrate) are byproducts of bacterial fermentation in the gut and are frequently reduced in people with diabetes, obesity, autoimmune disorders, and cancer. A growing body of research points to the role of SCFAs in governing the mechanism by which the gut microbiome affects host physiology - an exciting prospect considering the current…

Megan Mouw
Megan Mouw holds a Bachelor of Science in microbiology from McGill University (Canada). Driven by her experiences at UCSF medical center in San Francisco, Megan is passionate about the role that the gut microbiota plays in maintaining health and wellness. She is currently perusing graduate studies in Microbiology and Environmental Toxicology at the University of California Santa Cruz and hopes to share her love of science through writing.

Short-chain fatty acids (SCFAs) (such as acetate, propionate, butyrate) are byproducts of bacterial fermentation in the gut and are frequently reduced in people with diabetes, obesity, autoimmune disorders, and cancer. A growing body of research points to the role of SCFAs in governing the mechanism by which the gut microbiome affects host physiology - an exciting prospect considering the current…

Megan Mouw
Megan Mouw holds a Bachelor of Science in microbiology from McGill University (Canada). Driven by her experiences at UCSF medical center in San Francisco, Megan is passionate about the role that the gut microbiota plays in maintaining health and wellness. She is currently perusing graduate studies in Microbiology and Environmental Toxicology at the University of California Santa Cruz and hopes to share her love of science through writing.

How the gut microbiota can relate to preventing and treating obesity and what are the potential gut microbiota targets in gluten-related disorders were the key subjects discussed in the workshop on nutrition organized by GMFH during the Gut Microbiota for Health World Summit 2018, held in Rome on March 10 and 11. The workshop, called ‘Gut microbiota targets in nutrition’,…

GMFH Editing Team
GMFH Editing Team

How the gut microbiota can relate to preventing and treating obesity and what are the potential gut microbiota targets in gluten-related disorders were the key subjects discussed in the workshop on nutrition organized by GMFH during the Gut Microbiota for Health World Summit 2018, held in Rome on March 10 and 11. The workshop, called ‘Gut microbiota targets in nutrition’,…

GMFH Editing Team
GMFH Editing Team

During the past decade a large number of genomic studies have reported associations between our gut microbiota composition and metabolic disorders. However, a causal relationship between gut microbiota and metabolic diseases such as obesity or type 2 diabetes has yet to be confirmed. Furthermore, mechanisms by which gut microbes and their metabolites interact in the context of metabolic disorders have…

GMFH Editing Team
GMFH Editing Team

During the past decade a large number of genomic studies have reported associations between our gut microbiota composition and metabolic disorders. However, a causal relationship between gut microbiota and metabolic diseases such as obesity or type 2 diabetes has yet to be confirmed. Furthermore, mechanisms by which gut microbes and their metabolites interact in the context of metabolic disorders have…

GMFH Editing Team
GMFH Editing Team

The effects of dietary fiber on a host's innate immune responses are thought to be mediated at local and systemic levels via short-chain fatty acids (SCFAs). Previous preclinical research has shown that mice that consume a diet high in fermentable fiber are protected against allergic airway inflammation through SCFAs. However, underlying mechanisms are poorly understood. A new study, led by…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The effects of dietary fiber on a host's innate immune responses are thought to be mediated at local and systemic levels via short-chain fatty acids (SCFAs). Previous preclinical research has shown that mice that consume a diet high in fermentable fiber are protected against allergic airway inflammation through SCFAs. However, underlying mechanisms are poorly understood. A new study, led by…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Clostridium difficile infection (CDI) represents a major healthcare concern that causes diarrhea and usually affects people who have recently been treated with antibiotics or have had an extended stay in a healthcare setting. It can also spread easily to others. Although previous experimental research has shown that a fiber-deprived diet leads to a disturbed host colonic epithelium and has an…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Clostridium difficile infection (CDI) represents a major healthcare concern that causes diarrhea and usually affects people who have recently been treated with antibiotics or have had an extended stay in a healthcare setting. It can also spread easily to others. Although previous experimental research has shown that a fiber-deprived diet leads to a disturbed host colonic epithelium and has an…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados