by GMFH Editing Team
Yava L. Jones-Hall, Ariangela Kozik and Cindy Nakatsu from Purdue University, West Lafayette, Indiana, USA, have recently published a paper in PLoS ONE on the role of Tumor Necrosis Factor (TNF) in Inflammatory Bowel Disease (IBD) and the impact of this pro-inflammatory cytokine on the gut microbiota.
by GMFH Editing Team
Faecalibacterium prausnitzii is known for exhibiting anti-inflammatory effects in vitro and in vivo by secreted metabolites that block nuclear factor (NF)-κB activation. The low proportion of F. prausnitzii in the microbiome of Crohn’s disease patients characterizes the microbial dysbiosis associated with that condition.
Many disorders are associated with impaired function of the gut barrier. The gut microbiota regulates gut barrier function, and previous research has shown that modulation of gut microbiota shows promise for enhancing barrier integrity.
Dr. Yasmine Belkaid of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is chief of the Mucosal Immunology section and co-director of the trans-NIH metaorganisms initiative. Her work explores mechanisms at barrier sites (i.e.
by Patrice D. Cani
In this paper, the first aim we had with Dr. Amandine Everard, was to investigate whether some key molecules involved in the innate immune system, mainly MyD88 [myeloid differentiation primary response gene 88], may contribute to the development of obesity, diabetes and low grade inflammation.
The Inflammatory Bowel Diseases (IBDs), which include Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract.
by Satheesh Natarajan
TH17 (T helper 17) has emerged as a novel potential therapeutic agent for the control of intestinal inflammatory conditions. These cells are most abundant in the small intestinal lamina propris. IL-17 (Interleukin 17A) expressing CD4+T lymphocytes (Th17) cells naturally reside
Sahar El Aidy presented us her recent work about mice colonization as a model to study host-microbial homeostasis dynamics. This work was done under the supervision of Michiel Kleerebezem at Wageningen University (The Netherlands) : 1) What is your background
