Category : Gut Microbiota

As coordinating institute of the MetaHIT consortium and leading expert in gut microbiota research, the French INRA (National Institute for Agricultural Research) has officially inaugurated on July 2nd, 2013 the MetaGenoPolis project. The project receives its €19 million funding from the French Program "Investissements d'Avenir". It is designed as a demonstration initiative, seeking to establish the impact of the gut…

GMFH Editing Team
GMFH Editing Team

As coordinating institute of the MetaHIT consortium and leading expert in gut microbiota research, the French INRA (National Institute for Agricultural Research) has officially inaugurated on July 2nd, 2013 the MetaGenoPolis project. The project receives its €19 million funding from the French Program "Investissements d'Avenir". It is designed as a demonstration initiative, seeking to establish the impact of the gut…

GMFH Editing Team
GMFH Editing Team

There are many questions surrounding the relationship between the functioning of our human body and the presence of the microbes that live in and on us. The current state of knowledge does not allow us to fully understand what impact our microbiota has on our lives. To approach this question, it is important to find out how our gut metagenome…

GMFH Editing Team
GMFH Editing Team

There are many questions surrounding the relationship between the functioning of our human body and the presence of the microbes that live in and on us. The current state of knowledge does not allow us to fully understand what impact our microbiota has on our lives. To approach this question, it is important to find out how our gut metagenome…

GMFH Editing Team
GMFH Editing Team

The intestinal microbiota is known to modulate bioavailability and efficacy of endogenous compounds, nutrients or drugs, with large interindividual variations. The least conserved fraction of our microbiota may hence explain a stratification of the human population in converters and non converters for numerous compounds. As an example, the reduction of cholesterol to coprostanol is only active in a fraction of…

Fernando Aspiroz

The intestinal microbiota is known to modulate bioavailability and efficacy of endogenous compounds, nutrients or drugs, with large interindividual variations. The least conserved fraction of our microbiota may hence explain a stratification of the human population in converters and non converters for numerous compounds. As an example, the reduction of cholesterol to coprostanol is only active in a fraction of…

Fernando Aspiroz

Using mice models, scientists from UCL and WUR found that Akkermansia muciniphila could have a role in reversing high-fat diet-induced metabolic disorders, in this study obesity and type-2 diabetes. The two first authors, Amandine Everard and Clara Belzer, having respectively a background in Pharmaceutical Sciences and Molecular Microbiology accepted to give us their feedback on their main findings.   1)…

GMFH Editing Team
GMFH Editing Team

Using mice models, scientists from UCL and WUR found that Akkermansia muciniphila could have a role in reversing high-fat diet-induced metabolic disorders, in this study obesity and type-2 diabetes. The two first authors, Amandine Everard and Clara Belzer, having respectively a background in Pharmaceutical Sciences and Molecular Microbiology accepted to give us their feedback on their main findings.   1)…

GMFH Editing Team
GMFH Editing Team

During the Biovision Forum 2013, you chaired the session on the Gut Microbiota and moderated a round table on the subject. What are the main messages coming out of this event?   FL: I think it was an excellent initiative that the Biovision Forum got interested in the microbiota and that the topic was in the spotlight. The forum has…

GMFH Editing Team
GMFH Editing Team

During the Biovision Forum 2013, you chaired the session on the Gut Microbiota and moderated a round table on the subject. What are the main messages coming out of this event?   FL: I think it was an excellent initiative that the Biovision Forum got interested in the microbiota and that the topic was in the spotlight. The forum has…

GMFH Editing Team
GMFH Editing Team

Can you tell us a little bit about you and how you got interested in Gut Microbiota?   FL: I was trained as a geneticist. As a PhD student (2000-2003), I worked in a lab that used the Drosophila fly  as a model for research. My scientific questions were on immunity (infection resistance, especially those of bacterial origin) in Bruno…

GMFH Editing Team
GMFH Editing Team

Can you tell us a little bit about you and how you got interested in Gut Microbiota?   FL: I was trained as a geneticist. As a PhD student (2000-2003), I worked in a lab that used the Drosophila fly  as a model for research. My scientific questions were on immunity (infection resistance, especially those of bacterial origin) in Bruno…

GMFH Editing Team
GMFH Editing Team

American journalist Michael Pollan shares his experience with the American Gut Project and gives a full overview on the human microbiome as we know it today. "Here were the names of the hundreds of bacterial species that call me home. In sheer numbers, these microbes and their genes dwarf us. It turns out that we are only 10 percent human:…

GMFH Editing Team
GMFH Editing Team

American journalist Michael Pollan shares his experience with the American Gut Project and gives a full overview on the human microbiome as we know it today. "Here were the names of the hundreds of bacterial species that call me home. In sheer numbers, these microbes and their genes dwarf us. It turns out that we are only 10 percent human:…

GMFH Editing Team
GMFH Editing Team

Humans are not (and have never been) alone. From the moment we are born, millions of micro-organisms populate our bodies and coexist with us rather peacefully for the rest of our lives. This microbiome represents the totality of micro-organisms (and their genomes) that we necessarily acquire from the environment. Micro-organisms living in or on us have evolved to extract the…

GMFH Editing Team
GMFH Editing Team

Humans are not (and have never been) alone. From the moment we are born, millions of micro-organisms populate our bodies and coexist with us rather peacefully for the rest of our lives. This microbiome represents the totality of micro-organisms (and their genomes) that we necessarily acquire from the environment. Micro-organisms living in or on us have evolved to extract the…

GMFH Editing Team
GMFH Editing Team

Speakers: Giovanni Barbara (Italy), Magnus Simren (Sweden)   Prof. Barbara highlighted the fact that there is increasing evidence indicating that the gut microbiota may be involved in the pathogenesis and pathophysiology of functional gastrointestinal disorders (FGIDs). FGIDs are a group of disorders characterised by recurrent GI symptoms that cannot be explained by other pathologically-based disease. Of these, irritable bowel syndrome…

GMFH Editing Team
GMFH Editing Team

Speakers: Giovanni Barbara (Italy), Magnus Simren (Sweden)   Prof. Barbara highlighted the fact that there is increasing evidence indicating that the gut microbiota may be involved in the pathogenesis and pathophysiology of functional gastrointestinal disorders (FGIDs). FGIDs are a group of disorders characterised by recurrent GI symptoms that cannot be explained by other pathologically-based disease. Of these, irritable bowel syndrome…

GMFH Editing Team
GMFH Editing Team

Moderator: Francisco Guarner – Speakers: Karen Scott, Colin Hill   Karen Scott’s presentation was designed as a pedagogical introduction to the notion of prebiotics. She put forward the definition given in Gibson et al 2010:  “Prebiotics are a selectively fermented ingredient that results in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon host…

GMFH Editing Team
GMFH Editing Team

Moderator: Francisco Guarner – Speakers: Karen Scott, Colin Hill   Karen Scott’s presentation was designed as a pedagogical introduction to the notion of prebiotics. She put forward the definition given in Gibson et al 2010:  “Prebiotics are a selectively fermented ingredient that results in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon host…

GMFH Editing Team
GMFH Editing Team