Category : Gut Brain Axis

Parkinson’s disease is caused by the progressive loss of dopaminergic neurons and recent studies have widened the immune system and the gut microbiota's contribution to the disease. A new study in mice, led by researchers from the Université de Montréal and McGill University in Canada, shows the involvement of intestinal infections as a trigger in Parkinson’s disease through autoimmune mechanisms.…

GMFH Editing Team
GMFH Editing Team

Parkinson’s disease is caused by the progressive loss of dopaminergic neurons and recent studies have widened the immune system and the gut microbiota's contribution to the disease. A new study in mice, led by researchers from the Université de Montréal and McGill University in Canada, shows the involvement of intestinal infections as a trigger in Parkinson’s disease through autoimmune mechanisms.…

GMFH Editing Team
GMFH Editing Team

The microorganisms inhabiting the human gut can alter the chemical structures of drugs, leading to changes in their bioavailability, toxicity and efficacy. Although the gut microbial enzymes responsible for these chemical modifications are poorly understood, microbial mediation of therapeutic effects has been reported for metformin, chemotherapeutic drugs and antidepressants. A gut microbial enzymatic pathway is involved in metabolizing the drug…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The microorganisms inhabiting the human gut can alter the chemical structures of drugs, leading to changes in their bioavailability, toxicity and efficacy. Although the gut microbial enzymes responsible for these chemical modifications are poorly understood, microbial mediation of therapeutic effects has been reported for metformin, chemotherapeutic drugs and antidepressants. A gut microbial enzymatic pathway is involved in metabolizing the drug…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The enteric nervous system (ENS)—also called “our second brain”—is an autonomous part of the nervous system consisting of in the myenteric and submucosal plexus within the wall of the gastrointestinal tract. Comprising primary afferent neurons, interneurons and motor neurons, alongside intestinal cells involved in immune responses and endocrine and paracrine functions, it is involved in the sensory-motor control of the…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

The enteric nervous system (ENS)—also called “our second brain”—is an autonomous part of the nervous system consisting of in the myenteric and submucosal plexus within the wall of the gastrointestinal tract. Comprising primary afferent neurons, interneurons and motor neurons, alongside intestinal cells involved in immune responses and endocrine and paracrine functions, it is involved in the sensory-motor control of the…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

A current challenge in gut microbiome science is that of characterizing the effects of food groups on gut microbial communities instead of focusing on isolated nutrients. Although prebiotics provide health benefits by specifically altering the composition or activity of the gut microbiota, not all dietary fibers are prebiotics and they can benefit gut bacterial groups in different ways. A new…

GMFH Editing Team
GMFH Editing Team

A current challenge in gut microbiome science is that of characterizing the effects of food groups on gut microbial communities instead of focusing on isolated nutrients. Although prebiotics provide health benefits by specifically altering the composition or activity of the gut microbiota, not all dietary fibers are prebiotics and they can benefit gut bacterial groups in different ways. A new…

GMFH Editing Team
GMFH Editing Team

Autism spectrum disorder (ASD) involves a group of neurodevelopmental conditions characterized by impairments in social interactions and behavior. It is also accompanied by gastrointestinal dysfunction. According to World Health Organization, one child in 160 worldwide has ASD, which tends to persist into adolescence and adulthood. Beyond genes, environmental factors have been suggested to play a role in the onset of…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Autism spectrum disorder (ASD) involves a group of neurodevelopmental conditions characterized by impairments in social interactions and behavior. It is also accompanied by gastrointestinal dysfunction. According to World Health Organization, one child in 160 worldwide has ASD, which tends to persist into adolescence and adulthood. Beyond genes, environmental factors have been suggested to play a role in the onset of…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Experimental research has previously shown how the gut microbiota is involved in regulating brain function through the gut-brain axis. Depression and anxiety are among the most prevalent mental health conditions in industrialized countries and there is a current need for novel psychopharmacological medications to be developed for both conditions. Although the gut microbiota has been hypothesized to be involved in…

GMFH Editing Team
GMFH Editing Team

Experimental research has previously shown how the gut microbiota is involved in regulating brain function through the gut-brain axis. Depression and anxiety are among the most prevalent mental health conditions in industrialized countries and there is a current need for novel psychopharmacological medications to be developed for both conditions. Although the gut microbiota has been hypothesized to be involved in…

GMFH Editing Team
GMFH Editing Team

Together with diet, treatment with drugs is a major factor that influences gut microbiota composition. Indeed, the gut microbiota community may contribute to the therapeutic effects of certain drugs. For instance, metformin may act through a close interaction between Bacteroides fragilis, the bile acid glycoursodeoxycholic acid and intestinal farnesoid X receptor to improve metabolic dysfunction in individuals with type 2…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Together with diet, treatment with drugs is a major factor that influences gut microbiota composition. Indeed, the gut microbiota community may contribute to the therapeutic effects of certain drugs. For instance, metformin may act through a close interaction between Bacteroides fragilis, the bile acid glycoursodeoxycholic acid and intestinal farnesoid X receptor to improve metabolic dysfunction in individuals with type 2…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Modulating the gut microbiota has emerged as a means of affecting the central nervous system function and, thus, human behavior, especially in the context of stress, mood and anxiety disorders and even neurocognitive disorders. Clinical studies with probiotics using neuroimaging methods have started exploring the benefits of probiotics in the human brain. Among them, the probiotic Bifidobacterium longum 1714 has…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

Modulating the gut microbiota has emerged as a means of affecting the central nervous system function and, thus, human behavior, especially in the context of stress, mood and anxiety disorders and even neurocognitive disorders. Clinical studies with probiotics using neuroimaging methods have started exploring the benefits of probiotics in the human brain. Among them, the probiotic Bifidobacterium longum 1714 has…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

The increase in cardiovascular diseases (CVD) that comes with age has been related to an arterial dysfunction linked to higher inflammatory and oxidative stress responses. Although there is suggestion that a perturbed gut microbiome plays a role in the aging phenotype and the onset of physical frailty, the mechanisms that link changes in gut microbiome composition and an increased risk…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The increase in cardiovascular diseases (CVD) that comes with age has been related to an arterial dysfunction linked to higher inflammatory and oxidative stress responses. Although there is suggestion that a perturbed gut microbiome plays a role in the aging phenotype and the onset of physical frailty, the mechanisms that link changes in gut microbiome composition and an increased risk…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Microbiome studies carried out in the past decade have led to an enhanced understanding of the gut microbiome in human health. However, most of these studies have been carried out in western countries and the Indian gut microbiome is not well explored. Since dietary habits and lifestyle play a key role in shaping the gut microbiome, large differences in the…

Vineet K. Sharma
Dr. Sharma has been an Associate Professor at the Indian Institute of Science Education and Research Bhopal since July 2011. Dr. Sharma obtained his PhD in Bioinformatics and Biomedical Sciences from IGIB, New Delhi in 2006. After completing his doctoral research, he worked as a scientist at RIKEN, Japan for five years and joined IISER Bhopal after returning to India. He is also the founder and coordinator of the Innovation and Incubation Centre of Entrepreneurship (IICE) at IISER Bhopal. The main focus of Dr. Sharma’s lab is to reveal and analyze the human-associated microbiome among the Indian population and carry out comparative studies with different populations to gain functional insights, while also making comparisons with healthy and disease datasets. Dr. Sharma’s groups also recently sequenced the genome of the peacock, which is the national bird of India.

Microbiome studies carried out in the past decade have led to an enhanced understanding of the gut microbiome in human health. However, most of these studies have been carried out in western countries and the Indian gut microbiome is not well explored. Since dietary habits and lifestyle play a key role in shaping the gut microbiome, large differences in the…

Vineet K. Sharma
Dr. Sharma has been an Associate Professor at the Indian Institute of Science Education and Research Bhopal since July 2011. Dr. Sharma obtained his PhD in Bioinformatics and Biomedical Sciences from IGIB, New Delhi in 2006. After completing his doctoral research, he worked as a scientist at RIKEN, Japan for five years and joined IISER Bhopal after returning to India. He is also the founder and coordinator of the Innovation and Incubation Centre of Entrepreneurship (IICE) at IISER Bhopal. The main focus of Dr. Sharma’s lab is to reveal and analyze the human-associated microbiome among the Indian population and carry out comparative studies with different populations to gain functional insights, while also making comparisons with healthy and disease datasets. Dr. Sharma’s groups also recently sequenced the genome of the peacock, which is the national bird of India.