Differences in the gut microbiota in patients with IBD compared to healthy controls suggest that probiotics may be of help. This article takes an in-depth look into the rationale of using probiotics for IBD and summarizes the evidence from recent clinical guidelines for the use of probiotics in Crohn’s disease, ulcerative colitis and pouchitis.
Study identifies a role for bacterial proteases in Crohn’s disease
26 Jun 2023by Amber Hann, Heather Galipeau
Inflammatory bowel disease is a chronic remitting and relapsing condition that causes severe inflammation of the intestines and disabling bowel symptoms. It affects millions of lives globally, and although alterations in the gut microbiome have been associated with IBD, precise mechanisms remain incompletely understood. New research from McMaster University now implicates bacterial proteases in Crohn’s disease.
Keystone Bacteroides strain restitution leads to microbiome recovery and reduced risk of colitis in genetically susceptible mice
29 Mar 2022by Rene van den Wijngaard
Alterations in the gut microbiome in early life have been associated with increased risk of inflammatory bowel diseases. New findings in mice have found a keystone Bacteroides strain that reduces colitis risk when engrafted during early life in a gut microbiome disrupted by antibiotics.
Gut microbiota and host inflammation states: personalized treatments for ulcerative colitis remission
15 Nov 2021by GMFH Editing Team
Ulcerative colitis is a chronic debilitating inflammatory bowel disease with no curative treatment currently available. INRAE scientists have developed a novel predictive model of disease progression in pediatric patients that integrates both gut microbiota and host inflammation data.
Fecal bacterial protease activity may indicate progression to ulcerative colitis
14 Dec 2020by Heather Galipeau
Many studies have reported changes in gut microbiome composition in patients with inflammatory bowel disease, including ulcerative colitis, when compared with healthy individuals. While that clearly raises the question about the key role played by gut microbes in IBD pathogenesis, we have yet to pinpoint the causative microbes and their mechanisms.
New research sheds light on the effects of inflammatory bowel disease risk alleles on gut bacterial taxa
8 Apr 2019by GMFH Editing Team
Scientists struggle with elucidating how host and gut microbiome interact for shaping the genetic susceptibility of IBD. In 633 IBD patients, Harry Sokol and colleagues have found associations between genetic variants associated with a higher risk of IBD and the depletion of certain gut bacterial taxa.
The most significant achievements in gut microbiome science in 2018
27 Dec 2018by GMFH Editing Team
GMFH continue to cover the important progress made in our knowledge of the gut microbiota's impact on wellbeing and disease.
Baseline gut microbiome is associated with disease severity, progression and treatment efficacy in pediatric ulcerative colitis patients
26 Nov 2018by Andreu Prados
The researchers investigated the role of the gut microbiome in disease severity, progression and treatment response in 405 pediatric.
A mouse model of colitis shows the relevance of phages on intestinal inflammation
27 Sep 2018by Andreu Prados
A new study, led by Dr. Lora Hooper from the University of Texas Southwestern Medical Center in Dallas (Texas, USA), has found that compositional changes in intestinal phage communities occur during colitis in mice.
A new study elucidates how the immune system drives gut pathobiont-dependent inflammatory responses
19 Mar 2018by Andreu Prados
A new study as found that induced regulatory T (Treg) cells in the gut are critical for immune tolerance to gut pathobionts through the transcription factor c-MAF.