Differences in the gut microbiota in patients with IBD compared to healthy controls suggest that probiotics may be of help. This article takes an in-depth look into the rationale of using probiotics for IBD and summarizes the evidence from recent clinical guidelines for the use of probiotics in Crohn’s disease, ulcerative colitis and pouchitis.
Study identifies a role for bacterial proteases in Crohn’s disease
26 Jun 2023by Amber Hann, Heather Galipeau
Inflammatory bowel disease is a chronic remitting and relapsing condition that causes severe inflammation of the intestines and disabling bowel symptoms. It affects millions of lives globally, and although alterations in the gut microbiome have been associated with IBD, precise mechanisms remain incompletely understood. New research from McMaster University now implicates bacterial proteases in Crohn’s disease.
Targeting fungi for Crohn’s disease? A fungus used in the food industry for surface ripening cheese and meat is involved in impairing colonic healing
15 Sep 2021by Andreu Prados
Scientists have discovered a fungus that delays wound healing in mice and is enriched in inflamed tissue from patients with Crohn’s disease. The findings, coupled with the discovery of an engineered yeast that suppresses inflammation in a mouse model of colitis, highlights the potential of studying fungi-host interactions in IBD.
The inflammatory potential of diet is tied to Crohn’s disease risk but not to ulcerative colitis, suggests a new observational study
2 Nov 2020by Rene van den Wijngaard
Despite the fact that current guidelines for managing inflammatory bowel diseases do not devote attention to diet as a central element of treatment, there is an increasing amount of evidence that supports the role of diet in patients with IBD. A new nationwide cohort study shows the association between the level of inflammatory potential in diet and risk of Crohn’s disease.
Higher mucins production and an imbalanced gut microbiota found in Crohn´s Disease remission patients
26 Sep 2019by Allison Clark
Scientists struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New research in mice reveals that gut microbial metabolism alongside diet play a key role in modifying the extent of gut microbiome disruption in response to antibiotics.
The ileal mucosa-associated microbiota may help predict recurrence in patients with Crohn’s disease
20 Jun 2019by GMFH Editing Team
Clinicians struggle with finding a single risk marker for predicting early postoperative endoscopic recurrence in Crohn’s disease. Researchers from Saint Antoine Hospital and other institutions reveal that ileal mucosa-associated microbiota may help predict recurrence in patients with CD after ileocecal resection.
New research sheds light on the effects of inflammatory bowel disease risk alleles on gut bacterial taxa
8 Apr 2019by GMFH Editing Team
Scientists struggle with elucidating how host and gut microbiome interact for shaping the genetic susceptibility of IBD. In 633 IBD patients, Harry Sokol and colleagues have found associations between genetic variants associated with a higher risk of IBD and the depletion of certain gut bacterial taxa.
The most significant achievements in gut microbiome science in 2018
27 Dec 2018by GMFH Editing Team
GMFH continue to cover the important progress made in our knowledge of the gut microbiota's impact on wellbeing and disease.
New research supports the contribution of the gut microbiota in Crohn’s disease pathogenesis
13 Aug 2018by Andreu Prados
The researchers studied the influence of genotypic and phenotypic factors on the gut microbiota and characterized the mucosal microbiota in 21 patients with quiescent Crohn’s disease (CD), 17 young healthy siblings of CD patients and 19 unrelated healthy controls.
The timing of food consumption influences the human salivary microbiota
22 Mar 2018by Andreu Prados
A recent study has found that meal timing affects the daily rhythm of the human salivary microbiota and that timing differences may have a deleterious effect on the metabolism of the host.