Category : Cancer & Tumors

The gut microbiome has captured the attention of both researchers and society, and important progress was made in 2019 in our understanding of its emerging role in health and disease. Although gut microbiome science is moving progressively from the bench to the bedside, much research in the field has looked at cataloguing the composition and function of gut microbial communities,…

GMFH Editing Team
GMFH Editing Team

The gut microbiome has captured the attention of both researchers and society, and important progress was made in 2019 in our understanding of its emerging role in health and disease. Although gut microbiome science is moving progressively from the bench to the bedside, much research in the field has looked at cataloguing the composition and function of gut microbial communities,…

GMFH Editing Team
GMFH Editing Team

Genes alone cannot explain the current rise in colorectal cancer (CRC) and scientists are now trying to elucidate the gut microbiota's contribution as an important player. Previous human research has shown mechanisms by which the bacteria might affect tumorigenesis, especially in the early stages. However, gut microbiome signatures of CRC in association studies have not always been validated across different…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Genes alone cannot explain the current rise in colorectal cancer (CRC) and scientists are now trying to elucidate the gut microbiota's contribution as an important player. Previous human research has shown mechanisms by which the bacteria might affect tumorigenesis, especially in the early stages. However, gut microbiome signatures of CRC in association studies have not always been validated across different…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

One of the important roles played by the gut microbiota involves directing maturation of the mammalian immune system, although the molecular basis involved is still being characterized. As a result, the intimate relationships between commensal microorganisms and the host system are subject to an increasing amount of research into managing immune-related conditions. In particular, the induction of intestinal CD8 T…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

One of the important roles played by the gut microbiota involves directing maturation of the mammalian immune system, although the molecular basis involved is still being characterized. As a result, the intimate relationships between commensal microorganisms and the host system are subject to an increasing amount of research into managing immune-related conditions. In particular, the induction of intestinal CD8 T…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Mutations that lead to an impairment of tet methylcytosine dioxygenase 2 (Tet2) function or/and expression -  a gene that encodes an epigenetic modifier enzyme - have been related to the development of haematopoietic malignancies in both mice and humans. According to a new study in Nature by Marlies Meisel and Reinhard Hinterleitner from the University of Chicago and collaborators, gut…

Heather Galipeau
Heather Galipeau is a Research Associate at McMaster University (Canada) where she is researching dietary and microbial interactions in celiac disease and inflammatory bowel disease. She obtained her PhD in 2015 from McMaster University in Elena Verdu’s lab, during which she found that the small intestinal microbial background influences the degree of immuno-pathology triggered by dietary antigens, such as gluten.

Mutations that lead to an impairment of tet methylcytosine dioxygenase 2 (Tet2) function or/and expression -  a gene that encodes an epigenetic modifier enzyme - have been related to the development of haematopoietic malignancies in both mice and humans. According to a new study in Nature by Marlies Meisel and Reinhard Hinterleitner from the University of Chicago and collaborators, gut…

Heather Galipeau
Heather Galipeau is a Research Associate at McMaster University (Canada) where she is researching dietary and microbial interactions in celiac disease and inflammatory bowel disease. She obtained her PhD in 2015 from McMaster University in Elena Verdu’s lab, during which she found that the small intestinal microbial background influences the degree of immuno-pathology triggered by dietary antigens, such as gluten.

Mice models are widely used to assess the impact of exposure to environmental factors such as chemicals, drugs or infectious agents on host homeostasis through modulation of the gut microbiota. A new study, led by Dr. Guodong Zhang from the University of Massachusetts (USA), has found that exposure to triclosan increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Triclosan…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Mice models are widely used to assess the impact of exposure to environmental factors such as chemicals, drugs or infectious agents on host homeostasis through modulation of the gut microbiota. A new study, led by Dr. Guodong Zhang from the University of Massachusetts (USA), has found that exposure to triclosan increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Triclosan…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has found an association between colorectal cancer (CRC) and variations in the gut microbiome composition. Although mice research supports the theory that tumor development appears to be driven by interactions between the gut microbiome and host genomics, mechanisms involved in the crosstalk between colorectal carcinogenesis and the gut microbiome are still unknown. A new study, led by Prof.…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has found an association between colorectal cancer (CRC) and variations in the gut microbiome composition. Although mice research supports the theory that tumor development appears to be driven by interactions between the gut microbiome and host genomics, mechanisms involved in the crosstalk between colorectal carcinogenesis and the gut microbiome are still unknown. A new study, led by Prof.…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has pointed to the role of gut microbiota-host interactions in the effectiveness of immunotherapeutic agents (here; here). However, little is known regarding the potential role of the gut microbiota in the immune-mediated effects of drugs used as cancer immunotherapy. A review by Dr. Christian Jobin, from the Department of Medicine, Department of Infectious Diseases and Immunology, and Department…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has pointed to the role of gut microbiota-host interactions in the effectiveness of immunotherapeutic agents (here; here). However, little is known regarding the potential role of the gut microbiota in the immune-mediated effects of drugs used as cancer immunotherapy. A review by Dr. Christian Jobin, from the Department of Medicine, Department of Infectious Diseases and Immunology, and Department…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the human gut microbiota may mediate suppression of carcinogenesis through its interaction with host immunity. Among cancer types, colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in the United States. However, little is known regarding whether manipulating the gut microbiota could help in its prevention and…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the human gut microbiota may mediate suppression of carcinogenesis through its interaction with host immunity. Among cancer types, colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in the United States. However, little is known regarding whether manipulating the gut microbiota could help in its prevention and…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados