Category : Cancer & Tumors

Mutations that lead to an impairment of tet methylcytosine dioxygenase 2 (Tet2) function or/and expression -  a gene that encodes an epigenetic modifier enzyme - have been related to the development of haematopoietic malignancies in both mice and humans. According to a new study in Nature by Marlies Meisel and Reinhard Hinterleitner from the University of Chicago and collaborators, gut…

Heather Galipeau
Heather Galipeau is a Research Associate at McMaster University (Canada) where she is researching dietary and microbial interactions in celiac disease and inflammatory bowel disease. She obtained her PhD in 2015 from McMaster University in Elena Verdu’s lab, during which she found that the small intestinal microbial background influences the degree of immuno-pathology triggered by dietary antigens, such as gluten.

Mutations that lead to an impairment of tet methylcytosine dioxygenase 2 (Tet2) function or/and expression -  a gene that encodes an epigenetic modifier enzyme - have been related to the development of haematopoietic malignancies in both mice and humans. According to a new study in Nature by Marlies Meisel and Reinhard Hinterleitner from the University of Chicago and collaborators, gut…

Heather Galipeau
Heather Galipeau is a Research Associate at McMaster University (Canada) where she is researching dietary and microbial interactions in celiac disease and inflammatory bowel disease. She obtained her PhD in 2015 from McMaster University in Elena Verdu’s lab, during which she found that the small intestinal microbial background influences the degree of immuno-pathology triggered by dietary antigens, such as gluten.

Mice models are widely used to assess the impact of exposure to environmental factors such as chemicals, drugs or infectious agents on host homeostasis through modulation of the gut microbiota. A new study, led by Dr. Guodong Zhang from the University of Massachusetts (USA), has found that exposure to triclosan increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Triclosan…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Mice models are widely used to assess the impact of exposure to environmental factors such as chemicals, drugs or infectious agents on host homeostasis through modulation of the gut microbiota. A new study, led by Dr. Guodong Zhang from the University of Massachusetts (USA), has found that exposure to triclosan increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Triclosan…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has found an association between colorectal cancer (CRC) and variations in the gut microbiome composition. Although mice research supports the theory that tumor development appears to be driven by interactions between the gut microbiome and host genomics, mechanisms involved in the crosstalk between colorectal carcinogenesis and the gut microbiome are still unknown. A new study, led by Prof.…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has found an association between colorectal cancer (CRC) and variations in the gut microbiome composition. Although mice research supports the theory that tumor development appears to be driven by interactions between the gut microbiome and host genomics, mechanisms involved in the crosstalk between colorectal carcinogenesis and the gut microbiome are still unknown. A new study, led by Prof.…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has pointed to the role of gut microbiota-host interactions in the effectiveness of immunotherapeutic agents (here; here). However, little is known regarding the potential role of the gut microbiota in the immune-mediated effects of drugs used as cancer immunotherapy. A review by Dr. Christian Jobin, from the Department of Medicine, Department of Infectious Diseases and Immunology, and Department…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Recent research has pointed to the role of gut microbiota-host interactions in the effectiveness of immunotherapeutic agents (here; here). However, little is known regarding the potential role of the gut microbiota in the immune-mediated effects of drugs used as cancer immunotherapy. A review by Dr. Christian Jobin, from the Department of Medicine, Department of Infectious Diseases and Immunology, and Department…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the human gut microbiota may mediate suppression of carcinogenesis through its interaction with host immunity. Among cancer types, colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in the United States. However, little is known regarding whether manipulating the gut microbiota could help in its prevention and…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the human gut microbiota may mediate suppression of carcinogenesis through its interaction with host immunity. Among cancer types, colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in the United States. However, little is known regarding whether manipulating the gut microbiota could help in its prevention and…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Helicobacter pylori (Hp) chronic infection is increasing worldwide and is involved in the pathogenesis of chronic gastritis, peptic ulcers, and gastric cancer. Eradication of the bacterium through proton-pump inhibitor (PPI)-based triple therapy (PPI, amoxicillin and either clarithromycin or metronidazole and clarithromycin) or bismuth-based quadruple therapy (bismuth added to the standard twice-daily PPI-based triple therapy) has recently decreased, mainly due to…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

Helicobacter pylori (Hp) chronic infection is increasing worldwide and is involved in the pathogenesis of chronic gastritis, peptic ulcers, and gastric cancer. Eradication of the bacterium through proton-pump inhibitor (PPI)-based triple therapy (PPI, amoxicillin and either clarithromycin or metronidazole and clarithromycin) or bismuth-based quadruple therapy (bismuth added to the standard twice-daily PPI-based triple therapy) has recently decreased, mainly due to…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

Previous research has shown that the gut microbiome could influence cancer outcomes through its interaction with host immunity. Indeed, mouse studies have shown the anti-cancer effects of chemotherapeutic drugs such as cyclophosphamide and celecoxib could be mediated by commensal species. However, the mechanisms by which gut microbial communities influence response to chemotherapeutic drugs remains poorly understood. Two recent studies using…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the gut microbiome could influence cancer outcomes through its interaction with host immunity. Indeed, mouse studies have shown the anti-cancer effects of chemotherapeutic drugs such as cyclophosphamide and celecoxib could be mediated by commensal species. However, the mechanisms by which gut microbial communities influence response to chemotherapeutic drugs remains poorly understood. Two recent studies using…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the mechanisms of drug action such as chemopreventive activity of celecoxib and effects of metformin in type 2 diabetes patients appear to be shaped by gut microbial communities. A recent study, led by Dr. Laurence Zitvogel from the Institut de Cancérologie Gustave Roussy Cancer Campus in Villejuif (France), has found that the antitumoral efficacy of…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Previous research has shown that the mechanisms of drug action such as chemopreventive activity of celecoxib and effects of metformin in type 2 diabetes patients appear to be shaped by gut microbial communities. A recent study, led by Dr. Laurence Zitvogel from the Institut de Cancérologie Gustave Roussy Cancer Campus in Villejuif (France), has found that the antitumoral efficacy of…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Scientific evidence shows probiotics may have a role in treating acute infectious diarrhoea and preventing antibiotic-associated diarrhoea. However, little is known regarding their role in the treatment of diarrhoea generated as a result of radiotherapy or chemotherapy treatments. A recent systematic review and meta-analysis, led by Dr. C-X Pei from The First Clinical Medical College and Evidence Based Medical Centre…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

Scientific evidence shows probiotics may have a role in treating acute infectious diarrhoea and preventing antibiotic-associated diarrhoea. However, little is known regarding their role in the treatment of diarrhoea generated as a result of radiotherapy or chemotherapy treatments. A recent systematic review and meta-analysis, led by Dr. C-X Pei from The First Clinical Medical College and Evidence Based Medical Centre…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.