Oriol Juanola & Rubén Francés

Written by Oriol Juanola & Rubén Francés

Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).

The intestinal epithelial barrier is not just a static physical barrier but rather interacts continuously with the gut microbiome and immune cells. An intact intestinal barrier protects the host against invasion of microorganisms and toxins whereas at the same time it allows absorption of essential fluids and nutrients. The pathophysiology of cirrhosis is associated with a dysfunctional intestinal barrier, which…

Oriol Juanola & Rubén Francés
Oriol Juanola is a PhD. student of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University (Alicante, Spain). The group is interested in molecular and cellular aspects around the immune system that are responsible for the surveillance, response and regulation of homeostasis with our gut microbiota in the so-called "gut-liver axis", a central element in different metabolic pathologies within the scope of the gastroenterology and hepatology. The translation of these aspects, addressed from different methodological perspectives, to the clinical field is also relevant for the Group in order to improve the diagnosis, treatment and/or prognosis of these diseases. Rubén Francés is professor of Immunology and Head of the Hepatic and Intestinal Immunobiology Group at Miguel Hernández University and the Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD).