Stein and colleagues describe in their study, published in PLOS computational biology, how time series can help to study dynamics of the microbiota. Moreover, unlike usual cross sectional studies which lack a mechanistic understanding of the ecosystem's structure and its
Stein and colleagues describe in their study, published in PLOS computational biology, how time series can help to study dynamics of the microbiota. Moreover, unlike usual cross sectional studies which lack a mechanistic understanding of the ecosystem’s structure and its response to external perturbations, modelling dynamics can help to predict and recover the microbiota temporal dynamics. For example, they modeled how antibiotics can help Clostridium difficile to perpetuate the intestinal ecosystem.
Conceptual figure highlighting the difference between our approach and the currently available methods for microbiota analysis. Used input data are the temporal records of microbial total abundances (colored bars on left) and the temporal signal of external perturbations (e.g. presence/absence or concentration). (A) Example and list of current computational approaches used to analyze community data for microbiota studies. (B) Our approach uses ecological modeling to infer a network of microbial interactions, susceptibilities to external perturbations and growth rates. The inferred parameters are used in an ecological community model which can then be used to predict ecosystem dynamics and to identify steady states.
Beyond antibiotics, a wide range of commonly used non-antibiotic drugs can affect the gut microbiome. In addition, the gut microbiome can also influence an individual’s response to drugs by affecting their efficacy and safety. What are the implications of the bidirectional interaction between non-antibiotic drugs and the gut microbiome in the clinical setting?
Although the COVID-19 pandemic has shifted the focus of research for scientists worldwide, major breakthroughs in gut microbiome science have been made in 2020. In this last post of the year, we bring you articles from our blog that cover the major advances in the gut microbiome in 2020, from bench to bedside.
The metabolic activity of immune cells is enhanced after a viral infection, such as the one driven by COVID-19. Dietary approaches that support a healthy gut microbiome can benefit the immune system and ensure a good nutritional status that would help the host deal with pathogens.