Stein and colleagues describe in their study, published in PLOS computational biology, how time series can help to study dynamics of the microbiota. Moreover, unlike usual cross sectional studies which lack a mechanistic understanding of the ecosystem's structure and its
Stein and colleagues describe in their study, published in PLOS computational biology, how time series can help to study dynamics of the microbiota. Moreover, unlike usual cross sectional studies which lack a mechanistic understanding of the ecosystem’s structure and its response to external perturbations, modelling dynamics can help to predict and recover the microbiota temporal dynamics. For example, they modeled how antibiotics can help Clostridium difficile to perpetuate the intestinal ecosystem.
Conceptual figure highlighting the difference between our approach and the currently available methods for microbiota analysis. Used input data are the temporal records of microbial total abundances (colored bars on left) and the temporal signal of external perturbations (e.g. presence/absence or concentration). (A) Example and list of current computational approaches used to analyze community data for microbiota studies. (B) Our approach uses ecological modeling to infer a network of microbial interactions, susceptibilities to external perturbations and growth rates. The inferred parameters are used in an ecological community model which can then be used to predict ecosystem dynamics and to identify steady states.
Foods are processed in the upper digestive tract and pass into the colon when entering the digestive system. A new paper outlines the impact of food consumption in shaping bidirectional communication between digestive responses and the digestive sensations occurring before, during and after a meal.
The last 9th Gut Microbiota for Health World Summit hold in Madrid on March updated the science behind diet, the balance between gut microbiota and the immune system, mental health, food intolerances and functional gut disorders, among others. Check out here the Summit’s official report.
While patients infected with SARS-CoV-2 typically present with a respiratory illness, certain patients also report gastrointestinal symptoms. The presence of virus receptors in gastrointestinal epithelial cells and an altered gut microbiota composition in some patients might have implications for managing COVID-19.