Stein and colleagues describe in their study, published in PLOS computational biology, how time series can help to study dynamics of the microbiota. Moreover, unlike usual cross sectional studies which lack a mechanistic understanding of the ecosystem's structure and its
Stein and colleagues describe in their study, published in PLOS computational biology, how time series can help to study dynamics of the microbiota. Moreover, unlike usual cross sectional studies which lack a mechanistic understanding of the ecosystem’s structure and its response to external perturbations, modelling dynamics can help to predict and recover the microbiota temporal dynamics. For example, they modeled how antibiotics can help Clostridium difficile to perpetuate the intestinal ecosystem.
Conceptual figure highlighting the difference between our approach and the currently available methods for microbiota analysis. Used input data are the temporal records of microbial total abundances (colored bars on left) and the temporal signal of external perturbations (e.g. presence/absence or concentration). (A) Example and list of current computational approaches used to analyze community data for microbiota studies. (B) Our approach uses ecological modeling to infer a network of microbial interactions, susceptibilities to external perturbations and growth rates. The inferred parameters are used in an ecological community model which can then be used to predict ecosystem dynamics and to identify steady states.
Probiotics and their health benefits are often the subject of both conversations and questions. Today, GMFH’s editorial staff offers you a selection of material developed by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to better understand these bacteria.
An abnormal pattern of microbial colonization has been reported in infants born prior to 37 weeks of gestation. New research supports the role of probiotic supplementation in shaping the gut microbiota of preterm infants towards that of their full-term counterparts.
Irritable bowel syndrome is one of the most common disorders diagnosed by gastroenterologists. Peppermint oil, specific probiotics, psyllium supplementation, first-line IBS dietary advice, and a low FODMAP diet can aid in improving IBS symptoms.