Antibiotics, while essential in many cases, can disrupt the indigenous gut microbiota and leave a patient susceptible to antibiotic-resistant bacterial infections. In this study, researchers wanted to find out the potential benefit of proactive treatment with probiotics before the administration
Gut Microbiota Research & Practice is a section dedicated to promoting knowledge-sharing and debate among researchers, scientists and healthcare professionals. You will find a selection of discussions about articles from scientific literature as well as other content including interviews with experts, event reports, and special publications.
Akkermansia muciniphila and Faecalibacterium prausnitzii differentially affect host transcriptional response: focus on a powerful tool to study host-microbe interactions
21 Aug 2014by Patrice D. Cani
Numerous commensal bacteria present in the gut microbiota produce short chain fatty acids (SCFA’s) particularly acetate, butyrate and propionate. These SCFA’s have been associated with several biological effects upon host. Growing evidence suggests that specific microbes such as Faecalibacterium prausnitzii
Using a stress model in animals, Da Silva and colleagues induced gut hyperpermeability and visceral hypersensitivity as well as a shift in O-glycosylation of mucins, associated with flattening and loss of the mucus layer cohesive properties. The probiotic L. farciminis
Lawrence and colleagues tracked two subjects' microbiota over a year, collecting 800 fecal and saliva samples associated with 10,000 longitudinal measurements. They first highlighted the evidence for long-term, overall community stability, as differences between individuals were much larger than variation within
In a study published in Cancer Prevention Research, Dr. Patrick Schloss (University of Michigan) and his team found that the gut microbiome could enrich current methods of testing for colon cancer. The group characterized the gut microbiome from stool samples of
Interview with Dr. Karine Clément on human genes and microbial genes in obesity
12 Aug 2014by Kristina Campbell
Karine Clément is a physician and a professor at Paris 6 Pierre et Marie Curie University in Paris and director of an INSERM team. She is also the director of ICAN (Institute of Cardiometabolism and Nutrition),Pitié-Salpêtrière hospital, which focuses on care,
What effect does probiotic consumption have on blood pressure? This was the question that a systematic review in Hypertension set out to answer. Several databases were analysed, and publications were included if they met established criteria previously determined by
Dr. Francisco Guarner explains two recent contributions to the field
30 Jul 2014by Kristina Campbell
Two papers were recently published in Nature Biotechnology, both on the topic of finding out the content of gut microbiota samples. The Gut Microbiota for Health website previously covered both selections: The paper authored by Li et al. presented an updated collection
In an article published online on June 24, 2014 in the Journal of Clinical Investigation, Zhongyi Chen and Lilu Guo, from the Vanderbilt University, Nashville, Tennessee, USA, showed that the administration of a modified bacteria expressing therapeutic factors in the gut microbiota could reduce
Recommendations on probiotic and prebiotic treatments to improve nutritional status
23 Jul 2014by Kristina Campbell
This article is a collaboration of representatives from academia, medicine, and industry who came together at a workshop during the International Scientific Association for Probiotics and Prebiotics (ISAPP) held in Cork, Ireland in October, 2012. The goal of the workshop was
