by Andreu Prados
Cardiovascular diseases remain one of the most pressing public health concerns, demanding innovative research to identify novel causes. A recent Nature study reported that imidazole propionate made by gut bacteria contributes to atherosclerosis development, supporting its potential role as a biomarker of subclinical disease.
by Karen Madsen
Previous clinical studies have shown a promising role of fecal microbiota transplantation to induce remission in ulcerative colitis and maintain steroid-induced Crohn’s disease remission. A new double-blind, placebo-controlled trial found fecal microbiota transplantation is not effective at inducing clinical or endoscopic remission in adults with Crohn’s disease.
by Konstantina Zafeiropoulou
Crohn’s disease is an immune-mediated disease without a cure. While current guideline-based therapies are immune-directed therapies (small molecules and biologics), recent advances in understanding how the gut microbiome changes precede and drive disease offer potential for developing personalized therapeutics.
by Mónica Quinzo
Gut microbiota aids in fat digestion by converting primary bile acids into unconjugated and secondary bile acids. Recent research in mice has uncovered an intricate host-microbiota partnership in regulating bile acid production, helping to prevent excessive accumulation and maintain metabolic balance.
by Andreu Prados
Inflammation has been involved in the onset of chronic diseases. Probiotics emerge as a potential dietary tool for managing those conditions, partly through their role in immune system modulation and the anti-inflammatory response. Find out what is known about the anti-inflammatory effects of probiotics and their potential applications at the bedside.
by Rene van den Wijngaard
Despite the fact that current guidelines for managing inflammatory bowel diseases do not devote attention to diet as a central element of treatment, there is an increasing amount of evidence that supports the role of diet in patients with IBD. A new nationwide cohort study shows the association between the level of inflammatory potential in diet and risk of Crohn’s disease.
by Patrice D. Cani
Gut microbiota, with its close links to metabolism and the immune system, could potentially be a factor that lies at the core of good health. This means it can be positioned at the heart of the processes that influence the risk of contracting different diseases.
by Andreu Prados
The second phase of the Human Microbiome Project has recently been completed. Multi-omics of the gut microbial ecosystem has allowed for the discovery of new host-microbiome interactions that could help in precision medicine in those with IBDs and prediabetes.
by Andreu Prados
The mechanisms that link changes in gut microbiome composition and an increased risk of cardiovascular disease remain elusive. Changes in the gut microbiome related to aging may mediate arterial dysfunction, coupled with a normalization of inflammation, suggests a new mice study.
by GMFH Editing Team
GMFH continue to cover the important progress made in our knowledge of the gut microbiota's impact on wellbeing and disease.
