by GMFH Editing Team
Gut microbiome responses to antibiotics and their long-lasting effects on the host remain poorly characterized. A new mice study shows that amoxicillin-clavulanate for 7 days leads to personalized changes in gut microbiota composition and colonic transcriptome.
Circadian rhythms are also apparent within our gastrointestinal tract. Two new mice studies show that circadian rhythm and clock genes may also affect intestinal immune cells by boosting the secretion of cytokines that help maintain proper balance of the intestinal barrier.
by GMFH Editing Team
Imbalances in the gut microbiota composition have been described as a hallmark of certain liver diseases. Yi Duan from the University of California San Diego and colleagues have found in mice that specific phages targeting the gut-dwelling bacterium E. faecalis might be used to treat patients with alcoholic hepatitis.
by GMFH Editing Team
The causal contribution of commensal gut microorganisms in human immune responses is limited. A new study has found that disruptions in the gut microbiome secondary to antibiotics may adversely affect immunity to influenza vaccination in healthy adults.
by GMFH Editing Team
Scientists struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New research in mice reveals that gut microbial metabolism alongside diet play a key role in modifying the extent of gut microbiome disruption in response to antibiotics.
by Andreu Prados
The gut microbiota is a promising target to suppress food allergies through acting via regulatory T cells. New research in mice shed light on mechanisms by which early-life gut microbiota exerts a protective effect against IgE-mediated food allergies.
by Andreu Prados
The mechanisms that link changes in gut microbiome composition and an increased risk of cardiovascular disease remain elusive. Changes in the gut microbiome related to aging may mediate arterial dysfunction, coupled with a normalization of inflammation, suggests a new mice study.
by GMFH Editing Team
Contrary to common drugs, probiotics can evolve during treatment within the host. Scientists have tracked the behavior of E. coli Nissle 1917 in the mouse’s gut and shown that unbalanced gut microbiomes and different diets may affect how this bacterium evolves across the gastrointestinal tract.
by GMFH Editing Team
Scientists struggle with elucidating how host and gut microbiome interact for shaping the genetic susceptibility of IBD. In 633 IBD patients, Harry Sokol and colleagues have found associations between genetic variants associated with a higher risk of IBD and the depletion of certain gut bacterial taxa.
by GMFH Editing Team
Transforming the original food substrates through fermentation leads to the formation of nutrients and bioactive compounds with functional benefits. GMFH editors have had the chance to speak with Robert Hutkins regarding his recently launched book on the science behind fermented foods.