A recent randomised placebo-controlled trial, led by Prof. Thomas Borody from the Centre for Digestive Diseases in Sydney (Australia), has found that faecal microbiota transplantation induces clinical remission and endoscopic improvement in patients with active ulcerative colitis.

Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC) has shown mixed clinical results (see recent trials here and here). In a new pilot study, published as open access, Faming Zhang and colleagues tested the safety and efficacy of a "step-up" FMT strategy in 15 steroid-dependent UC patients.

Digestive disorders, from gut discomfort to inflammatory bowel diseases (IBD) and cancer, are rising in many countries. Research and clinical studies on the interaction of gut microbiota and digestive health, are providing stimulating data. However, their connection is not fully understood and gut fungi have recently been suggested to play a role as well.