by Andreu Prados
Gut fungi found in the lower gastrointestinal tract can influence the host immune system just like the bacterial microbiota. This article focuses on the role of the gut mycobiota in immune system homeostasis and its relevance for host health.
by Rene van den Wijngaard
Alterations in the gut microbiome in early life have been associated with increased risk of inflammatory bowel diseases. New findings in mice have found a keystone Bacteroides strain that reduces colitis risk when engrafted during early life in a gut microbiome disrupted by antibiotics.
by GMFH Editing Team
Ulcerative colitis is a chronic debilitating inflammatory bowel disease with no curative treatment currently available. INRAE scientists have developed a novel predictive model of disease progression in pediatric patients that integrates both gut microbiota and host inflammation data.
by Andreu Prados
Scientists have discovered a fungus that delays wound healing in mice and is enriched in inflamed tissue from patients with Crohn’s disease. The findings, coupled with the discovery of an engineered yeast that suppresses inflammation in a mouse model of colitis, highlights the potential of studying fungi-host interactions in IBD.
by Rene van den Wijngaard
Abdominal pain affects a huge amount of people nowadays, though its underlying mechanisms are not always understood. New findings in mice and humans reveal that localized immune responses against harmless foods might be involved in persistent “functional” abdominal pain.
by Heather Galipeau
Many studies have reported changes in gut microbiome composition in patients with inflammatory bowel disease, including ulcerative colitis, when compared with healthy individuals. While that clearly raises the question about the key role played by gut microbes in IBD pathogenesis, we have yet to pinpoint the causative microbes and their mechanisms.
by Rene van den Wijngaard
Despite the fact that current guidelines for managing inflammatory bowel diseases do not devote attention to diet as a central element of treatment, there is an increasing amount of evidence that supports the role of diet in patients with IBD. A new nationwide cohort study shows the association between the level of inflammatory potential in diet and risk of Crohn’s disease.
by GMFH Editing Team
How pregnancy can impact an offspring’s gut microbiota is unknown. New research reveals that children born to mothers with IBD present an altered gut microbiota composition and lower diversity, transferring abnormalities in the adaptive immune system to germ-free mice.
by Paul Enck
An increasing amount of scientific evidence supports the role of diet in the management of IBD in its early stages. Here, Prof. Paul Enck updates preclinical and clinical research disentangling the contribution of diet as an ally in managing IBD through the gut microbiome.
by Allison Clark
Scientists struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New research in mice reveals that gut microbial metabolism alongside diet play a key role in modifying the extent of gut microbiome disruption in response to antibiotics.
