A recent study, led by Dr. Wendy A. Henderson from the National Institute of Nursing Research at National Institutes of Health (NIH) in Bethesda (USA), and co-authored by Research Fellow Dr. Nicolaas Fourie, has found that the oral microbiota could be a useful source of information in patients with irritable bowel syndrome (IBS).

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, affecting more than 10% of the population, with the highest impact in women. Although its origin is still unknown, reduced gut microbial diversity could be involved in its development.

Authors of this paper attempted a meta-analysis of 56 studies on single-strain and multi-strain probiotics for the treatment of IBS, but trials were so heterogeneous when it came to probiotic concentration, duration of treatment, and methodology, that the meta-analysis was abandoned.

What influences gut motility?

4 Nov 2015

by Paul Enck

Authors of a new Cell paper gave groups of germ-free mice fecal microbiota samples from six healthy adults representing five different habitual diets: American (both a standard diet and a 'primal' diet), Bangladeshi, Malawian, and Amerindian.

Previous research has shown that adults with irritable bowel syndrome (IBS) who adopt a low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diet show an improvement in symptoms within 2 days. Would the low FODMAP diet have the same effect in childhood IBS? Does the gut microbiota predict the success of the diet in children who respond to this dietary intervention?

Recently, an (open-access) article co-authored with colleagues Hans Törnblom & Magnus Simrén appeared in Nature Reviews Gastroenterology and Hepatology - Crosstalk at the mucosal border: importance of the gut microenvironment in IBS.