2025 has been a productive year in gut microbiome research, spanning metabolic health, neurogastroenterology, immune modulation, and precision nutrition. In this ‘Year in Review’ article, the GMFH editing team describes their pick of the top GMFH-covered advances in 2025, outlining their impact in the clinical setting and implications for current and future research.
The 6th biennial meeting of the European Society of Neurogastroenterology and Motility, held at Queen Mary University of London, UK, from 4-6 September 2025, covered basic, translational, and clinical research in neurogastroenterology, including dietary therapies and ‘biotics’ for the management of gastrointestinal disorders. Find out more about the main takeaways from the conference.
Patients’ expectations and beliefs in IBS: Why gluten and wheat might not be the culprit
30 Sep 2025by Andreu Prados
Many patients with IBS find that wheat or gluten triggers gastrointestinal symptoms, prompting them to exclude these foods from their diets. A new study highlights how patients’ expectations and beliefs shape symptom modulation and dietary choices in IBS.
Digestive Disease Week 2025 featured recent basic, translational, and clinical research into the microbiome. Find out more about the main takeaways relevant for your clinical practice selected by GMFH editors.
Precision therapy in Crohn’s disease: Why the microbiome should be part of the equation
25 Aug 2025by Konstantina Zafeiropoulou
Crohn’s disease is an immune-mediated disease without a cure. While current guideline-based therapies are immune-directed therapies (small molecules and biologics), recent advances in understanding how the gut microbiome changes precede and drive disease offer potential for developing personalized therapeutics.
Emerging research suggests a complex interaction between the gut microbiome and endometriosis. Recent studies have begun to explore the impact of dietary interventions on endometriosis.
Clinical translation of microbiome research: takeaways from the 2025 GMFH Summit
16 May 2025by Andreu Prados
The 13th Gut Microbiota for Health World Summit took place 15-16 March 2025 in Washington, D.C., and it focused on advances in microbiome research to diagnose, prevent, and manage gastrointestinal and extra-intestinal conditions. Find out more about the most valuable takeaways from the event.
Carbohydrate malabsorption is an underlying cause of irritable bowel syndrome-type symptoms in some patients. This article explores the impact of fermentable short-chain carbohydrates (FODMAPs) on gut function, the benefits and risks of a low-FODMAP diet, and how probiotics can help individuals with carbohydrate malabsorption.
Scientists uncover a new way by which gut microbes control cholesterol levels
24 Feb 2025by Mónica Quinzo
Gut microbiota aids in fat digestion by converting primary bile acids into unconjugated and secondary bile acids. Recent research in mice has uncovered an intricate host-microbiota partnership in regulating bile acid production, helping to prevent excessive accumulation and maintain metabolic balance.
The human gut microbiome is packed with enzymes that can transform food, drugs, or pollutants. New research maps interactions between dietary xenobiotics and the gut microbiome, explaining why diet can work differently for different people.
