A blueprint for engineering human commensal bacteria
In a new journal, Cell Systems, Mimee et al. report that in their M.I.T. lab they succeeded in modulating the constitutive gene expression of the mammalian commensal bacterium Bacteroides thetaiotaomicron.
In a new journal, Cell Systems, Mimee et al. report that in their M.I.T. lab they succeeded in modulating the constitutive gene expression of the mammalian commensal bacterium Bacteroides thetaiotaomicron. They used the CRISPR interference methodology and validated the results of various gene modifications, from knockdown genes to repression, in mice colonized with the modified strain after antibiotic treatment. These results present a new way to explore cellular sensing, learn more about the host-microbe interface in the gut, and potentially change the gut ecosystem.
Mimee M, et al. (2015) Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota. Cell Systems 1(1), pp. 62-71. doi:10.1016/j.cels.2015.06.001
GMFH Editing Team
GMFH Editing Team
Following the GMFH 2022 Year at a Glance report, it is time for a flashback in the latest research on cancer microbiome. This post ranges between the epidemiology, etiology and diagnosis of cancer, looking at the role of fungal and bacterial gut microbiome in all three health care branches.
Significant strides have been made in our comprehension of the role of the gut microbiome in health and disease throughout the year 2022. We invite you to take a closer look at the "2022 Year at a Glance" report and learn about the groundbreaking discoveries made.
The Human Microbiome Action project is inviting experts in microbiome-based biomarker development to participate in a Delphi survey.