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Moderated by Paul W O'Toole and Joël Doré (@dorejoel)   Moderators aimed to make technical differences between the two categories of microbial community analysis, to help understand methods involved in gut microbiota analysis and to answer clinical questions involving analysis of the microbiota.   The human gut microbiota is the collection of bacteria, archea, virus and fungi. Paul O'Toole indicated that microbiome is a collection of genes inside microbiota and metagenomics is the method that consists in analyzing all genes of microbiota. Paul O'Toole summarized molecular tools available to investigate gut microbiota. There are two major approaches: studying phylogenetic marker using 16 rRNA genes amplification by pyrosequencing (called 16S barcodes…

Can you tell us about your experience prior to Enterome?   PR: I worked for 14 years as a general practitioner, a family doctor and even as a country doctor. I think it’s worth mentioning because my interest for gut microbiota is based on my experience as a field doctor. This is what I call the “earthly approach to medicine”. I’m no researcher and to me it’s a critical element in Enterome’s philosophy. We put a lot of efforts in designing pragmatic solutions to answer simple questions: “what can we do in the interest of patients? How can we facilitate practitioners’ activity?” We are here to find medical applications further…

Dr Alice Liou, first author of a recent article published in Science Translational Medicine,  gives us some clarification about gastric bypass effect on intestinal microbiota.   1) What is your background ?   I am a gastrointestinal physiologist with an interest in understanding the contributions of the gastrointestinal tract in regulating energy balance and metabolism. I received my DVM (veterinary) degree and my PhD degree in physiology at the University of California, Davis. Under the mentorship of both Helen Raybould at UC Davis and Stephen Wank at the National Institutes of Health, I studied the mechanisms of luminal nutrient sensing by enteroendocrine cells of the gastrointestinal tract. Since 2010, I’ve…

In a healthy adult, microbial cells are estimated to outnumber human cells 10 to one. Many microbes maintain our health, while others cause illness. Recent investigations of the human gut microbiome have discovered important ways in which gut microbes may influence a number of important disease states including obesity, inflammatory bowel disease, functional gastrointestinal disorders, cancers and liver disease. Recognizing the major influence the gut microbiome is likely to have on the future of digestive disease research and patient care, the AGA Governing Board is pleased to announce the creation of the AGA Center for Gut Microbiome Research and Education. "The gut microbiome is among the most exciting and promising areas of…

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Moderated by Paul W O'Toole and Joël Doré (@dorejoel)   Moderators aimed to make technical differences between the two categories of microbial community analysis, to help understand methods involved in gut microbiota analysis and to answer clinical questions involving analysis of the microbiota.   The human gut microbiota is the collection of bacteria, archea, virus and fungi. Paul O'Toole indicated that microbiome is a collection of genes inside microbiota and metagenomics is the method that consists in analyzing all genes of microbiota. Paul O'Toole summarized molecular tools available to investigate gut microbiota. There are two major approaches: studying phylogenetic marker using 16 rRNA genes amplification by pyrosequencing (called 16S barcodes…

Can you tell us about your experience prior to Enterome?   PR: I worked for 14 years as a general practitioner, a family doctor and even as a country doctor. I think it’s worth mentioning because my interest for gut microbiota is based on my experience as a field doctor. This is what I call the “earthly approach to medicine”. I’m no researcher and to me it’s a critical element in Enterome’s philosophy. We put a lot of efforts in designing pragmatic solutions to answer simple questions: “what can we do in the interest of patients? How can we facilitate practitioners’ activity?” We are here to find medical applications further…

Dr Alice Liou, first author of a recent article published in Science Translational Medicine,  gives us some clarification about gastric bypass effect on intestinal microbiota.   1) What is your background ?   I am a gastrointestinal physiologist with an interest in understanding the contributions of the gastrointestinal tract in regulating energy balance and metabolism. I received my DVM (veterinary) degree and my PhD degree in physiology at the University of California, Davis. Under the mentorship of both Helen Raybould at UC Davis and Stephen Wank at the National Institutes of Health, I studied the mechanisms of luminal nutrient sensing by enteroendocrine cells of the gastrointestinal tract. Since 2010, I’ve…

In a healthy adult, microbial cells are estimated to outnumber human cells 10 to one. Many microbes maintain our health, while others cause illness. Recent investigations of the human gut microbiome have discovered important ways in which gut microbes may influence a number of important disease states including obesity, inflammatory bowel disease, functional gastrointestinal disorders, cancers and liver disease. Recognizing the major influence the gut microbiome is likely to have on the future of digestive disease research and patient care, the AGA Governing Board is pleased to announce the creation of the AGA Center for Gut Microbiome Research and Education. "The gut microbiome is among the most exciting and promising areas of…

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