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Speakers: Emeran Mayer (USA), Premysl Bercik (Canada)   Prof. Mayer gave an introductory overview of the different aspects of the topic, stressing that the tight interplay between brain, gut and gut microbiota is based on a highly complex network of bidirectional pathways, which run top down (from brain to gut) as well as bottom up (from gut to brain). Prof. Mayer pointed out that the role of the brain in functional bowel disorders has been accepted for quite a long time, while it is only recently that the gastrointestinal (GI) community is beginning to acknowledge that the brain also plays a role in other GI diseases.   However, it remains…

Moderator: Francisco Guarner – Speakers: Karen Scott, Colin Hill   Karen Scott’s presentation was designed as a pedagogical introduction to the notion of prebiotics. She put forward the definition given in Gibson et al 2010:  “Prebiotics are a selectively fermented ingredient that results in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon host health”  Put into simple words, Prebiotics are “food” for the bacteria, normally living in the large intestine. Further to the definition, Karen Scott went on giving some elements of context about the gut microbiota.   She insisted on the fact that the gut microbiota was a complex and diverse bacterial…

Speakers: Dirk Haller (Germany), Balfour Sartor (USA)   Prof. Haller started his presentation by pointing out that “dysbiosis” is not a good term, because nobody knows what dysbiosis really means. To be able to understand what dysbiosis is, you would have to understand what the normal status quo is, and according to Prof. Haller that is not really well established. What is well established, as shown by a study with monozygotic twin cohorts, is a richness of gut bacteria in the healthy twins (cohorts from Germany and Lithuania), whereas in the ulcerative colitis-associated cohorts there is a dramatic decrease in bacterial richness. This drop in diversity can be observed in…

Speakers: Anne Vrieze (Netherlands), Lawrence Brandt (USA)   Dr Vrieze’s talk focused on faecal microbiota transplantation (FMT) as a therapy for metabolic syndrome and C. difficile inflammation (CDI), under the guiding question whether the lacking diversity of the gut microbiota, which is assumed to play a major role in the disease onset, can be restored by the infusion of donor faeces.   After having pointed to the long history of FMT, which dates back to the 4th century BC, Dr Vrieze started with a description of the FMT procedure at the Academic Medical Center (AMC) Amsterdam. A crucial step is the prior screening of the donors in order to avoid…

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Latest articles

Speakers: Emeran Mayer (USA), Premysl Bercik (Canada)   Prof. Mayer gave an introductory overview of the different aspects of the topic, stressing that the tight interplay between brain, gut and gut microbiota is based on a highly complex network of bidirectional pathways, which run top down (from brain to gut) as well as bottom up (from gut to brain). Prof. Mayer pointed out that the role of the brain in functional bowel disorders has been accepted for quite a long time, while it is only recently that the gastrointestinal (GI) community is beginning to acknowledge that the brain also plays a role in other GI diseases.   However, it remains…

Moderator: Francisco Guarner – Speakers: Karen Scott, Colin Hill   Karen Scott’s presentation was designed as a pedagogical introduction to the notion of prebiotics. She put forward the definition given in Gibson et al 2010:  “Prebiotics are a selectively fermented ingredient that results in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon host health”  Put into simple words, Prebiotics are “food” for the bacteria, normally living in the large intestine. Further to the definition, Karen Scott went on giving some elements of context about the gut microbiota.   She insisted on the fact that the gut microbiota was a complex and diverse bacterial…

Speakers: Dirk Haller (Germany), Balfour Sartor (USA)   Prof. Haller started his presentation by pointing out that “dysbiosis” is not a good term, because nobody knows what dysbiosis really means. To be able to understand what dysbiosis is, you would have to understand what the normal status quo is, and according to Prof. Haller that is not really well established. What is well established, as shown by a study with monozygotic twin cohorts, is a richness of gut bacteria in the healthy twins (cohorts from Germany and Lithuania), whereas in the ulcerative colitis-associated cohorts there is a dramatic decrease in bacterial richness. This drop in diversity can be observed in…

Speakers: Anne Vrieze (Netherlands), Lawrence Brandt (USA)   Dr Vrieze’s talk focused on faecal microbiota transplantation (FMT) as a therapy for metabolic syndrome and C. difficile inflammation (CDI), under the guiding question whether the lacking diversity of the gut microbiota, which is assumed to play a major role in the disease onset, can be restored by the infusion of donor faeces.   After having pointed to the long history of FMT, which dates back to the 4th century BC, Dr Vrieze started with a description of the FMT procedure at the Academic Medical Center (AMC) Amsterdam. A crucial step is the prior screening of the donors in order to avoid…

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