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Faecal microbiota transplantation (FMT) has emerged as an effective treatment for Clostridium difficile infections that were stubborn to antibiotic therapy. However, other clinical indications of FMT are receiving an increasing attention due to the relevant roles of the microbiota in the function of the gastrointestinal tract and other aspects of human physiology. In consequence, studies of FMT for recurrent Clostridium difficile infection or other indications could require submission of an investigational new drug (IND) application. An IND application is required in the United States by the US Food and Drug Administration (FDA). The FDA regulates clinical studies to evaluate their safety and efficacy, and the IND is necessary whenever clinical…

This basic research sought to better understand how soluble dietary fibers exert their beneficial effect on body weight and glucose control. The researchers show that two short-chain fatty acids, which are produced by fermentation of soluble fiber by gut bacteria, activate intestinal gluconeogenesis (IGN) gene expression through different, but complementary, mechanisms. One of the mechanisms activates IGN gene expression through a gut-brain neural circuit. Researchers observed that the regulation of IGN in mice is crucial for realizing the metabolic benefits associated with ingestion of soluble fiber. Here is the key point of the study from Gilles Mithieux lab : Propionate directly initiates portal-brain neural communication. Butyrate and propionate induce intestinal gluconeogenesis…

Filipe De Vadder is a molecular biologist in Gilles Mithieux group and published recently an important article in Cell journal which illustrate how gut microbiota fermentation product could impact neural communication. He accepted for GMFH…

Until now, the role of specific gut microbes in shaping body composition was poorly understood. A new study carried out by researchers in the Washington University School of Medicine in St. Louis clarified how diet and gut microbes interact to affect weight gain.   In this study, Ridaura and colleagues transplanted intact uncultured fecal microbiota from adult female twin pairs with differing body mass index (BMI) into separate groups of recipient adult germ-free mice. According to the researchers, the use of twins discordant for obesity provided an opportunity to examine interrelations between obesity and its associated metabolic disorders, diet, and the gut microbiota. Moreover, the transplantation facilitated the identification of…

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Latest articles

Faecal microbiota transplantation (FMT) has emerged as an effective treatment for Clostridium difficile infections that were stubborn to antibiotic therapy. However, other clinical indications of FMT are receiving an increasing attention due to the relevant roles of the microbiota in the function of the gastrointestinal tract and other aspects of human physiology. In consequence, studies of FMT for recurrent Clostridium difficile infection or other indications could require submission of an investigational new drug (IND) application. An IND application is required in the United States by the US Food and Drug Administration (FDA). The FDA regulates clinical studies to evaluate their safety and efficacy, and the IND is necessary whenever clinical…

This basic research sought to better understand how soluble dietary fibers exert their beneficial effect on body weight and glucose control. The researchers show that two short-chain fatty acids, which are produced by fermentation of soluble fiber by gut bacteria, activate intestinal gluconeogenesis (IGN) gene expression through different, but complementary, mechanisms. One of the mechanisms activates IGN gene expression through a gut-brain neural circuit. Researchers observed that the regulation of IGN in mice is crucial for realizing the metabolic benefits associated with ingestion of soluble fiber. Here is the key point of the study from Gilles Mithieux lab : Propionate directly initiates portal-brain neural communication. Butyrate and propionate induce intestinal gluconeogenesis…

Filipe De Vadder is a molecular biologist in Gilles Mithieux group and published recently an important article in Cell journal which illustrate how gut microbiota fermentation product could impact neural communication. He accepted for GMFH…

Until now, the role of specific gut microbes in shaping body composition was poorly understood. A new study carried out by researchers in the Washington University School of Medicine in St. Louis clarified how diet and gut microbes interact to affect weight gain.   In this study, Ridaura and colleagues transplanted intact uncultured fecal microbiota from adult female twin pairs with differing body mass index (BMI) into separate groups of recipient adult germ-free mice. According to the researchers, the use of twins discordant for obesity provided an opportunity to examine interrelations between obesity and its associated metabolic disorders, diet, and the gut microbiota. Moreover, the transplantation facilitated the identification of…

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