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There are many questions surrounding the relationship between the functioning of our human body and the presence of the microbes that live in and on us. The current state of knowledge does not allow us to fully understand what impact our microbiota has on our lives. To approach this question, it is important to find out how our gut metagenome interacts with our own genome. On July 18th, 2013, Science Magazine published an interesting paper called "The Hologenomic Basis of Speciation: Gut Bacteria Cause Hybrid Lethality in the Genus Nasonia", authored by Brucker and Bordenstein from the Vanderbilt University. For this study, the researchers used three species of wasps of the Nasonia genus.…

The Canadian Digestive Health Foundation organized the 4th annual Digestive Health Summit for Healthcare Professionals that took place on Tuesday 5th November, 2013 in Toronto at the Allstream Center. You can check the program and…

The intestinal microbiota is known to modulate bioavailability and efficacy of endogenous compounds, nutrients or drugs, with large interindividual variations. The least conserved fraction of our microbiota may hence explain a stratification of the human population in converters and non converters for numerous compounds. As an example, the reduction of cholesterol to coprostanol is only active in a fraction of the human population and it is directly associated with the population levels of active Bacteroides dorei (Gerard et al. 2007). The team of Peter Turnbaugh (Haiser et al. Science 2013) just published that Egghertella lenta, an actinobacterium of the human intestinal microbiota, can metabolize the drug Digoxin, used in cardiac…

A conference about relation between gut microbiota and colorectal cancer (CRC) was organized by the Canceropole in Paris this June 28th. Experts presented their studies linking different topics : the host microbiota crosstalk, associations between bacteria and cancer and how microbiota could impact antibiotics and anticancer therapies.   Gerard Eberl from Pasteur Institute started the conference insisting about the importance of microbiota and its potential symbiosis regarding mucosal immunity. Gut microbiota is different among different niches and in case of disease, microbes could take some advantage to growth in specific niche. Host and its microbiota could be seen as a super-organism, a holobiont. There is equilibrium between the microbiota and…

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Latest articles

There are many questions surrounding the relationship between the functioning of our human body and the presence of the microbes that live in and on us. The current state of knowledge does not allow us to fully understand what impact our microbiota has on our lives. To approach this question, it is important to find out how our gut metagenome interacts with our own genome. On July 18th, 2013, Science Magazine published an interesting paper called "The Hologenomic Basis of Speciation: Gut Bacteria Cause Hybrid Lethality in the Genus Nasonia", authored by Brucker and Bordenstein from the Vanderbilt University. For this study, the researchers used three species of wasps of the Nasonia genus.…

The Canadian Digestive Health Foundation organized the 4th annual Digestive Health Summit for Healthcare Professionals that took place on Tuesday 5th November, 2013 in Toronto at the Allstream Center. You can check the program and…

The intestinal microbiota is known to modulate bioavailability and efficacy of endogenous compounds, nutrients or drugs, with large interindividual variations. The least conserved fraction of our microbiota may hence explain a stratification of the human population in converters and non converters for numerous compounds. As an example, the reduction of cholesterol to coprostanol is only active in a fraction of the human population and it is directly associated with the population levels of active Bacteroides dorei (Gerard et al. 2007). The team of Peter Turnbaugh (Haiser et al. Science 2013) just published that Egghertella lenta, an actinobacterium of the human intestinal microbiota, can metabolize the drug Digoxin, used in cardiac…

A conference about relation between gut microbiota and colorectal cancer (CRC) was organized by the Canceropole in Paris this June 28th. Experts presented their studies linking different topics : the host microbiota crosstalk, associations between bacteria and cancer and how microbiota could impact antibiotics and anticancer therapies.   Gerard Eberl from Pasteur Institute started the conference insisting about the importance of microbiota and its potential symbiosis regarding mucosal immunity. Gut microbiota is different among different niches and in case of disease, microbes could take some advantage to growth in specific niche. Host and its microbiota could be seen as a super-organism, a holobiont. There is equilibrium between the microbiota and…

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