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The team of Jeffrey Gordon (Ridaura et al. Science 2013) published that the phenotype of obesity (increased adiposity) of an obese twin in a discordant twin pair is transmissible. In other words, they found that mice receiving an obese twin’s fecal microbiota display a greater fat mass than the mice receiving lean twin’s gut microbes. Cohousing is widely used in mice studies to investigate the impact of sharing microbial communities (mice are coprophagic) on the host phenotype. In this paper, they found that cohousing obese and lean animals prevents increased adiposity. Thus obese cohoused mice exhibited a lower increased adiposity compared with obese animals that had never been exposed to…

Some individuals seem to be more susceptible to develop obesity or are more resistant to weight loss during dietary restriction. Emerging evidence suggest that few bacterial genera (i.e., Bifidobacterium, Lactobacillus, Faecalibacterium and Akkermansia) are inversely associated with obesity, metabolic inflammation and related metabolic disorders in both human and rodent studies. However so far, a common integrative factor is still being sought. Researchers from the MetaHIT and MicroObes consortium published in Nature two joint-papers showing that richness of gut microbial genes and eventually microbial composition correlates with metabolic markers (e.g., body weight, fat mass, glucose and lipid metabolism, inflammation) and susceptibility to lose weight upon dietary restriction. Interestingly, using different sequencing…

  Although there are numerous studies focusing on structure and function of the gut microbiota, very few is known finally regarding the gut microbial colonization and the host homeostasis.  Some studies already focused on the structural dynamics of the early life gut microbiota, but little is known about factor which allows bacteria to establish in the gut and how the host responds to this colonization factors. Recent studies tried to decipher those mechanism using models. Sarkis Mazmanian group used Bacteroides fragilis strains and mutant with germ free mice to characterize commensal colonization factors. For instance, they observed that a specific locus is upregulated during the colonization in gut mice and…

As coordinating institute of the MetaHIT consortium and leading expert in gut microbiota research, the French INRA (National Institute for Agricultural Research) has officially inaugurated on July 2nd, 2013 the MetaGenoPolis project. The project receives its €19 million funding from the French Program "Investissements d'Avenir". It is designed as a demonstration initiative, seeking to establish the impact of the gut microbiota on our health and well being, paving the way for future applications in medicine and nutrition.   You can also visit their website for more information : http://mgps.eu

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The team of Jeffrey Gordon (Ridaura et al. Science 2013) published that the phenotype of obesity (increased adiposity) of an obese twin in a discordant twin pair is transmissible. In other words, they found that mice receiving an obese twin’s fecal microbiota display a greater fat mass than the mice receiving lean twin’s gut microbes. Cohousing is widely used in mice studies to investigate the impact of sharing microbial communities (mice are coprophagic) on the host phenotype. In this paper, they found that cohousing obese and lean animals prevents increased adiposity. Thus obese cohoused mice exhibited a lower increased adiposity compared with obese animals that had never been exposed to…

Some individuals seem to be more susceptible to develop obesity or are more resistant to weight loss during dietary restriction. Emerging evidence suggest that few bacterial genera (i.e., Bifidobacterium, Lactobacillus, Faecalibacterium and Akkermansia) are inversely associated with obesity, metabolic inflammation and related metabolic disorders in both human and rodent studies. However so far, a common integrative factor is still being sought. Researchers from the MetaHIT and MicroObes consortium published in Nature two joint-papers showing that richness of gut microbial genes and eventually microbial composition correlates with metabolic markers (e.g., body weight, fat mass, glucose and lipid metabolism, inflammation) and susceptibility to lose weight upon dietary restriction. Interestingly, using different sequencing…

  Although there are numerous studies focusing on structure and function of the gut microbiota, very few is known finally regarding the gut microbial colonization and the host homeostasis.  Some studies already focused on the structural dynamics of the early life gut microbiota, but little is known about factor which allows bacteria to establish in the gut and how the host responds to this colonization factors. Recent studies tried to decipher those mechanism using models. Sarkis Mazmanian group used Bacteroides fragilis strains and mutant with germ free mice to characterize commensal colonization factors. For instance, they observed that a specific locus is upregulated during the colonization in gut mice and…

As coordinating institute of the MetaHIT consortium and leading expert in gut microbiota research, the French INRA (National Institute for Agricultural Research) has officially inaugurated on July 2nd, 2013 the MetaGenoPolis project. The project receives its €19 million funding from the French Program "Investissements d'Avenir". It is designed as a demonstration initiative, seeking to establish the impact of the gut microbiota on our health and well being, paving the way for future applications in medicine and nutrition.   You can also visit their website for more information : http://mgps.eu

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