Starting at birth and continuing through the life span, we live in harmony with the bacteria and other microorganisms we host in our gut – a dynamic collection called the gut microbiota.

These hundreds of trillions of bacteria are crucial for our health. They play a key role in important body functions, from keeping the digestive system running to helping the immune system defend against intruders like disease-causing viruses.

But sometimes, the gut microbiota can be disturbed: a situation that scientists call “dysbiosis”.

 

References:

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Peterson CT, Sharma V, Elmén L, Peterson SN. Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. Clin Exp Immunol. 2015;179(3):363-377. doi:10.1111/cei.12474.

Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-230. doi:10.1038/nature11550.

Brown K, DeCoffe D, Molcan E, Gibson DL. Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease. Nutrients. 2012;4(8):1095-1119. doi:10.3390/nu4081095.

Petersen C, Round JL, Huttenhower C, et al. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014;16(7):1024-1033. doi:10.1111/cmi.12308.

Valdés L, Cuervo A, Salazar N, Ruas-Madiedo P, Gueimonde M, González S. The relationship between phenolic compounds from diet and microbiota: impact on human health. Food Funct. 2015;6(8):2424-2439. doi:10.1039/C5FO00322A.

van Baarlen P, Wells JM, Kleerebezem M. Regulation of intestinal homeostasis and immunity with probiotic lactobacilli. Trends Immunol. 2013;34(5):208-215. doi:10.1016/j.it.2013.01.005.

Tojo R, Suárez A, Clemente MG, et al. Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World J Gastroenterol. 2014;20(41):15163-15176. doi:10.3748/wjg.v20.i41.15163.

Rastall RA, Gibson GR. Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health. Curr Opin Biotechnol. 2015;32:42-46. doi:10.1016/j.copbio.2014.11.002.

Chen W-X, Ren L-H, Shi R-H. Enteric microbiota leads to new therapeutic strategies for ulcerative colitis. World J Gastroenterol. 2014;20(42):15657. doi:10.3748/wjg.v20.i42.15657.

GMFH Editing Team
GMFH Editing Team