With the advancement of medicine, our population is undergoing a prolonged aging process. Over the next three decades, the global population aged over 65 years is set to more than double, reaching a staggering 1.5 billion individuals. The emergence of the gut microbiota as a potent modulator of healthy aging requires a concerted effort to allocate resources and research towards developing interventions aimed at promoting optimal gut health and longevity.
Probiotics with an anti-inflammatory effect may reduce abdominal pain and hours of hospitalization in adult patients with acute uncomplicated diverticulitis
19 Apr 2022by Andreu Prados
The involvement of the gut microbiota in diverticulitis is gaining interest. This article explores what we know so far about the role of the gut microbiota in diverticulitis and discusses two recent clinical trials on the role of probiotics in managing acute uncomplicated diverticulitis.
Does functional abdominal pain have an organic explanation? Gut-localized immune responses offer new clues for patients with functional gastrointestinal disorders
8 Mar 2021by Rene van den Wijngaard
Abdominal pain affects a huge amount of people nowadays, though its underlying mechanisms are not always understood. New findings in mice and humans reveal that localized immune responses against harmless foods might be involved in persistent “functional” abdominal pain.
Will gut microbiota provide the solution to all of our health problems?
23 Apr 2020by Patrice D. Cani
Gut microbiota, with its close links to metabolism and the immune system, could potentially be a factor that lies at the core of good health. This means it can be positioned at the heart of the processes that influence the risk of contracting different diseases.
Findings in mice show alcoholic hepatitis has a microbial component and could be tackled by specific phages
30 Dec 2019by GMFH Editing Team
Imbalances in the gut microbiota composition have been described as a hallmark of certain liver diseases. Yi Duan from the University of California San Diego and colleagues have found in mice that specific phages targeting the gut-dwelling bacterium E. faecalis might be used to treat patients with alcoholic hepatitis.
Gut microbiome changes emerge as a potential modulator of age-associated cardiovascular disease risk
15 Apr 2019by Andreu Prados
The mechanisms that link changes in gut microbiome composition and an increased risk of cardiovascular disease remain elusive. Changes in the gut microbiome related to aging may mediate arterial dysfunction, coupled with a normalization of inflammation, suggests a new mice study.
New research sheds light on the effects of inflammatory bowel disease risk alleles on gut bacterial taxa
8 Apr 2019by GMFH Editing Team
Scientists struggle with elucidating how host and gut microbiome interact for shaping the genetic susceptibility of IBD. In 633 IBD patients, Harry Sokol and colleagues have found associations between genetic variants associated with a higher risk of IBD and the depletion of certain gut bacterial taxa.
The most significant achievements in gut microbiome science in 2018
27 Dec 2018by GMFH Editing Team
GMFH continue to cover the important progress made in our knowledge of the gut microbiota's impact on wellbeing and disease.
Microbiota plays key role in shaping intestinal barrier structure and permeability
31 Oct 2018by Heather Galipeau
The effects of the microbiota on immunity and metabolism have been well characterized, but the basic understanding of how microbes influence the overall structure and function of the intestinal barrier is not well understood.
How science shows that nutrition, the gut microbiota and immunity can improve resilience
22 Oct 2018by Andreu Prados
In the presence of pathogenic invaders and other noxious insults, a resilient immune response is crucial to effectively eliminate the source of stimulation in a way that does not harm the host.