A recent review, led by Dr. Purnima S. Kumar from the Division of Periodontology at College of Dentistry at The Ohio State University in Columbus (USA), examines the role of periodontal pathobionts in initiating or exacerbating systemic diseases.
Early-life antibiotic treatment may accelerate type 1 diabetes onset in non-obese diabetic mice
26 Oct 2016by Andreu Prados
A recent study, led by Dr. Martin J. Blaser from the Departments of Medicine and Microbiology at New York University Langone Medical Centre in New York (USA), has found that early-life antibiotic exposure in non-obese diabetic mice may accelerate T1D development.
Could the gut microbiota be a new potential target for multiple sclerosis treatment and prevention?
29 Aug 2016by Andreu Prados
A recent study, led by Dr. Ashutosh Mangalam, assistant professor of pathology at the University of Iowa Carver College of Medicine in Iowa City (USA), has found that gut microbiota changes may contribute to the disease course of multiple sclerosis.
Butyrate may have a protective effect in the development of type 1 diabetes
8 Aug 2016by Andreu Prados
It has been previously reported that the gut microbiota could be involved in the pathogenesis of metabolic diseases such as diabetes. A recent study, led by Dr. Wolfgang zu Castell from the Scientific Computing Research Unit at Helmholtz Zentrum München in Munich (Germany) has found that butyrate may have a protective effect in the pathogenesis of type 1 diabetes.
New insights into the role of gut microbiota in individuals with systemic lupus erythematosus
23 Jun 2016by Andreu Prados
A new study, led by Dr. Ana Suárez from the Department of Functional Biology at Faculty of Medicine in the University of Oviedo (Asturias, Spain), has found that intestinal microbiota changes promote a pro-inflammatory environment in SLE patients.
A recent study of humans with celiac disease who were treated with helminths raised the possibility that an increase in microbial species richness (i.e. the number of different species present) could regulate gluten-induced inflammation in the gut.
Rheumatoid arthritis (RA) is a debilitating immune disorder of unknown cause.
Digestive Disease Week AGA Symposium: Celiac Disease and Gut Microbiota
20 Jul 2015by Stefan Jellbauer
Quality and quantity of gluten, maturity of gut functions influencing antigen trafficking and handling (e.g. pattern recognition receptors and barrier function) and changes in microbiome composition are factors that contribute to the pathogenesis of the disease.
A long-term goal of gut microbiota research is to find a method of normalizing the microbiota early in life and sustaining it though the lifespan.
Deletion of MyD88 in intestinal epithelial cells partially protects against diet-induced obesity
26 Feb 2015by Patrice D. Cani
In this paper, the first aim we had with Dr. Amandine Everard, was to investigate whether some key molecules involved in the innate immune system, mainly MyD88 [myeloid differentiation primary response gene 88], may contribute to the development of obesity, diabetes and low grade inflammation.
